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  • Table of Contents — March 06, 2013, 5 (175) | Science Translational Medicine
    Frédérique Caillot Sébastien Calbo Stéphanie Le Corre Annick Lim Brigitte Lemercier Brigitte Le Mauff Maud Maho Vaillant Serge Jacquot Christophe Bedane Philippe Bernard Frédéric Caux Catherine Prost Emmanuel Delaporte Marie Sylvie Doutre Brigitte Dreno Nathalie Franck Saskia Ingen Housz Oro Olivier Chosidow Christine Pauwels Catherine Picard Jean Claude Roujeau Michèle Sigal Emmanuelle Tancrede Bohin Isabelle Templier Rüdiger Eming Michael Hertl Michel D Incan Pascal Joly Philippe Musette Science Translational Medicine 06 Mar 2013 175ra30 Changes in the B cell repertoire mediate long lasting therapeutic effects of rituximab in pemphigus patients Editor s Summary Abstract Full Text PDF Phenylbutyrate Therapy for Pyruvate Dehydrogenase Complex Deficiency and Lactic Acidosis By Rosa Ferriero Giuseppe Manco Eleonora Lamantea Edoardo Nusco Maria I Ferrante Paolo Sordino Peter W Stacpoole Brendan Lee Massimo Zeviani Nicola Brunetti Pierri Science Translational Medicine 06 Mar 2013 175ra31 Phenylbutyrate enhances pyruvate dehydrogenase enzyme complex PDHC activity through inhibition of PDHC kinase rescues the severe phenotype of a zebrafish model of PDHC deficiency and prevents systemic lactic acidosis Editor s Summary Abstract Full Text PDF Editors Choice Dead or Alive Nanopatrols Report By Natalie Artzi Science Translational Medicine 06 Mar 2013 175ec38 New nanosensor based imaging platform reports on transplanted cell viability Full Text Mast Cells Help Bacteria Hang Out After the Party By Christopher R Polage Science Translational Medicine 06 Mar 2013 175ec39 Mast cell derived IL 10 shifts the bladder towards immune tolerance and limits adaptive immunity to pathogens Full Text Energy Hunting tin By Anne Schaefer Science Translational Medicine 06 Mar 2013 175ec40 Vesicles move down neuronal axons powered by local glycolysis a process that requires huntingtin the protein defective in Huntington s disease Full Text Imaging the Beating Heart By David A Zidar Science Translational Medicine 06 Mar 2013 175ec41 Intravital microscopy of mouse hearts reveals rapid

    Original URL path: http://stm.sciencemag.org/content/5/175 (2016-02-10)
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  • Table of Contents — March 13, 2013, 5 (176) | Science Translational Medicine
    that emerges in blood after seasonal influenza vaccinations correlates with the development of protective antibody responses Editor s Summary Abstract Full Text PDF Targeting the Intracellular WT1 Oncogene Product with a Therapeutic Human Antibody By Tao Dao Su Yan Nicholas Veomett Dmitry Pankov Liang Zhou Tatyana Korontsvit Andrew Scott Joseph Whitten Peter Maslak Emily Casey Taochao Tan Hong Liu Victoria Zakhaleva Michael Curcio Ekaterina Doubrovina Richard J O Reilly Cheng Liu David A Scheinberg Science Translational Medicine 13 Mar 2013 176ra33 A therapeutic monoclonal antibody specific for the intracellular oncoprotein Wilms tumor 1 treats human leukemias in mice Editor s Summary Abstract Full Text PDF Proteoglycan 4 Expression Protects Against the Development of Osteoarthritis By Merry Z C Ruan Ayelet Erez Kilian Guse Brian Dawson Terry Bertin Yuqing Chen Ming Ming Jiang Jason Yustein Francis Gannon Brendan H L Lee Science Translational Medicine 13 Mar 2013 176ra34 Proteoglycan 4 protects from age related and posttraumatic osteoarthritis development Editor s Summary Abstract Full Text PDF Editors Choice A Jagged Edge to Cancer Chemoresistance By Cyrus M Ghajar Science Translational Medicine 13 Mar 2013 176ec42 Endothelial cells stimulate the cancer stem cell phenotype in human colorectal cancer cells by cleaving a Notch ligand Full Text Gut Reaction Microbiome Provides a Clue to Gender Bias in Autoimmunity By Margaret K Callahan Science Translational Medicine 13 Mar 2013 176ec43 The gut microbiome may regulate hormone levels thus contributing to gender bias in autoimmunity Full Text Lights of Hope in the Treatment of Epilepsy By Tore Eid Science Translational Medicine 13 Mar 2013 176ec44 Optogenetic control of neuronal excitability in the thalamus can interrupt seizures in a rat model of epilepsy Full Text Heart Versus Lungs in Hypertension Tug of War By Adriano R Tonelli Science Translational Medicine 13 Mar 2013 176ec45 The beneficial effects

    Original URL path: http://stm.sciencemag.org/content/5/176 (2016-02-10)
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  • Table of Contents — March 20, 2013, 5 (177) | Science Translational Medicine
    in Humans By Simon Reinke Sven Geissler William R Taylor Katharina Schmidt Bleek Kerstin Juelke Verena Schwachmeyer Michael Dahne Tony Hartwig Levent Akyüz Christian Meisel Nadine Unterwalder Navrag B Singh Petra Reinke Norbert P Haas Hans Dieter Volk Georg N Duda Science Translational Medicine 20 Mar 2013 177ra36 A subset of T cells inhibits bone regeneration in humans Editor s Summary Abstract Full Text PDF Quinolone 3 Diarylethers A New Class of Antimalarial Drug By Aaron Nilsen Alexis N LaCrue Karen L White Isaac P Forquer R Matthew Cross Jutta Marfurt Michael W Mather Michael J Delves David M Shackleford Fabian E Saenz Joanne M Morrisey Jessica Steuten Tina Mutka Yuexin Li Grennady Wirjanata Eileen Ryan Sandra Duffy Jane Xu Kelly Boni F Sebayang Anne Marie Zeeman Rintis Noviyanti Robert E Sinden Clemens H M Kocken Ric N Price Vicky M Avery Iñigo Angulo Barturen María Belén Jiménez Díaz Santiago Ferrer Esperanza Herreros Laura M Sanz Francisco Javier Gamo Ian Bathurst Jeremy N Burrows Peter Siegl R Kiplin Guy Rolf W Winter Akhil B Vaidya Susan A Charman Dennis E Kyle Roman Manetsch Michael K Riscoe Science Translational Medicine 20 Mar 2013 177ra37 ELQ 300 an investigational drug for treating and preventing malaria shows potent transmission blocking activity in rodent models of malaria Editor s Summary Abstract Full Text PDF CD19 Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy Refractory Acute Lymphoblastic Leukemia By Renier J Brentjens Marco L Davila Isabelle Riviere Jae Park Xiuyan Wang Lindsay G Cowell Shirley Bartido Jolanta Stefanski Clare Taylor Malgorzata Olszewska Oriana Borquez Ojeda Jinrong Qu Teresa Wasielewska Qing He Yvette Bernal Ivelise V Rijo Cyrus Hedvat Rachel Kobos Kevin Curran Peter Steinherz Joseph Jurcic Todd Rosenblat Peter Maslak Mark Frattini Michel Sadelain Science Translational Medicine 20 Mar 2013 177ra38 Five adults with chemotherapy refractory B ALL were induced into molecular remissions after treatment with CD19 CAR targeted T cells Editor s Summary Abstract Full Text PDF Editors Choice A Stroke of Insight By William J Mack Science Translational Medicine 20 Mar 2013 177ec46 A combination of intravenous t PA and endovascular therapy is not more effective than t PA alone for treating patients with moderate to severe acute ischemic stroke Full Text Ovarian Stem Cells Find Their Niche By Trudy G Oliver Science Translational Medicine 20 Mar 2013 177ec47 A population of stem cells in the mouse hilum are prone to epithelial ovarian cancer Full Text Neurons Themselves May Shy Away from Normal Interactions in Autism By Vikaas Sohal Science Translational Medicine 20 Mar 2013 177ec48 This study suggests that in some forms of autism neurons may abnormally retract their dendrites in response to stimulation Full Text High RANKs for Diabetes and Osteoporosis By Amir Tirosh Science Translational Medicine 20 Mar 2013 177ec49 Blockade of RANKL signaling a known approach for treating osteoporosis may also improve liver insulin resistance and diabetes Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine

    Original URL path: http://stm.sciencemag.org/content/5/177 (2016-02-10)
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  • Table of Contents — March 27, 2013, 5 (178) | Science Translational Medicine
    in the absence of toxicity Editor s Summary Abstract Full Text PDF NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis By Ritika Khandpur Carmelo Carmona Rivera Anuradha Vivekanandan Giri Alison Gizinski Srilakshmi Yalavarthi Jason S Knight Sean Friday Sam Li Rajiv M Patel Venkataraman Subramanian Paul Thompson Pojen Chen David A Fox Subramaniam Pennathur Mariana J Kaplan Science Translational Medicine 27 Mar 2013 178ra40 Neutrophil NETs may contribute to pathogenesis of rheumatoid arthritis Editor s Summary Abstract Full Text PDF Conserved Shifts in the Gut Microbiota Due to Gastric Bypass Reduce Host Weight and Adiposity By Alice P Liou Melissa Paziuk Jesus Mario Luevano Jr Sriram Machineni Peter J Turnbaugh Lee M Kaplan Science Translational Medicine 27 Mar 2013 178ra41 Alterations in the gastrointestinal microbiota caused by gastric bypass surgery are sufficient to trigger decreased body weight and adiposity in germ free mouse recipients Editor s Summary Abstract Full Text PDF State of the Art Review Statistical Challenges in the Evaluation of Treatments for Small Patient Populations By Edward L Korn Lisa M McShane Boris Freidlin Science Translational Medicine 27 Mar 2013 178sr3 Creative clinical trial designs can help to address the statistical challenges associated with small patient populations Abstract Full Text PDF Editors Choice Shape Matters Too By Edward Kai Hua Chow Science Translational Medicine 27 Mar 2013 178ec50 Nanoparticle shape can affect the specificity and efficacy of therapeutic antibodies targeting cancer Full Text Paying Our Sleep Debt in Extra Pounds By Ania Jastreboff Science Translational Medicine 27 Mar 2013 178ec51 People who get insufficient sleep eat more to balance their energy expenditure but may overcompensate causing weight gain Full Text Genomics of T ALL Reveals a Weapon of an Evasive Foe By Adam A Margolin Science Translational Medicine 27 Mar 2013 178ec52 Genomic profiling of T ALL samples at diagnosis remission and relapse identifies NT5C2 as a chemoresistance gene Full Text Sticky Substrates Snatch Bugs from Blood By Erkin Seker Science Translational Medicine 27 Mar 2013 178ec53 Magnetic nanoparticles conjugated with a synthetic ligand remove bacteria from whole blood while sparing red blood cells Full Text Erratum A Correction to the Research Article Titled Mucosal Imprinting of Vaccine Induced CD8 T Cells Is Crucial to Inhibit the Growth of Mucosal Tumors by F Sandoval M Terme M Nizard C Badoual M F Bureau L Freyburger O Clement E Marcheteau A Gey G Fraisse C Bouguin N Merillon E Dransart T Tran F Quintin Colonna G Autret M Thiebaud M Suleman S Riffault T C Wu O Launay C Danel J Taieb J Richardson L Zitvogel W H Fridman L Johannes E Tartour Science Translational Medicine 27 Mar 2013 178er2 Full Text PDF More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit About The Cover ONLINE COVER Bright Lights Small Trials The lights of Manhattan

    Original URL path: http://stm.sciencemag.org/content/5/178 (2016-02-10)
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  • Table of Contents — April 03, 2013, 5 (179) | Science Translational Medicine
    Terrence P Mcdonald Anthony L Gotter Scott D Kuduk Paul J Coleman Christopher J Winrow John J Renger Science Translational Medicine 03 Apr 2013 179ra44 Selective orexin receptor antagonism promotes sleep at doses lower than those that impair attention and memory in contrast to the GABA receptor positive allosteric modulators currently in use Editor s Summary Abstract Full Text PDF Inertial Focusing for Tumor Antigen Dependent and Independent Sorting of Rare Circulating Tumor Cells By Emre Ozkumur Ajay M Shah Jordan C Ciciliano Benjamin L Emmink David T Miyamoto Elena Brachtel Min Yu Pin i Chen Bailey Morgan Julie Trautwein Anya Kimura Sudarshana Sengupta Shannon L Stott Nezihi Murat Karabacak Thomas A Barber John R Walsh Kyle Smith Philipp S Spuhler James P Sullivan Richard J Lee David T Ting Xi Luo Alice T Shaw Aditya Bardia Lecia V Sequist David N Louis Shyamala Maheswaran Ravi Kapur Daniel A Haber Mehmet Toner Science Translational Medicine 03 Apr 2013 179ra47 A multistage microfluidic chip is capable of sorting rare EpCAM and EpCAM CTCs from cancer patients whole blood Editor s Summary Abstract Full Text PDF Editors Choice Skin Substitutes Already Done or Just the Beginning By Mercedes Balcells Science Translational Medicine 03 Apr 2013 179ec54 Laser assisted bioprinting can create a cellularized skin substitute to heal wounds Full Text The Gut Microbiome and Malnutrition By Mustafa Mahfuz Science Translational Medicine 03 Apr 2013 179ec55 A new study shows that a dysfunctional gut microbiome may contribute to a form of severe acute malnutrition called kwashiorkor Full Text Taking the Road Less Traveled RAS Meets PI3K PDK1 By Goutham Narla Science Translational Medicine 03 Apr 2013 179ec56 PI3K is a critical and druggable downstream effector of RAS signaling in pancreatic cancer Full Text Making Sense of Missense Mutations By Benjamin M Neale Science Translational Medicine 03 Apr 2013 179ec57 Genetic variation that is deleterious is on average younger than neutral variation Full Text Accessing the Inaccessible Genome By Benjamin F Voight Science Translational Medicine 03 Apr 2013 179ec58 Families with a rare kidney disease have a single base frameshift mutation within a MUC1 repeat region not found with whole genome sequencing Full Text Letters Comment on Time to Integrate Clinical and Research Informatics By Clement J McDonald Daniel J Vreeman Swapna Abhyankar Science Translational Medicine 03 Apr 2013 179le1 The same code standards should be used in both research and clinical care to facilitate data integration across domains Abstract Full Text PDF Author Response to Comment on Time to Integrate Clinical and Research Informatics By Irene L Katzan Richard A Rudick Science Translational Medicine 03 Apr 2013 179lr1 Lack of structured clinical data limits research potential of EHRs and efforts to establish clinical data standards should be a priority Abstract Full Text PDF Podcast Science Translational Medicine Podcast 3 April 2013 By Jason Uslaner Orla Smith Science Translational Medicine 03 Apr 2013 179pc2 In this podcast Jason Uslaner discusses the discovery of a new class of sleep inducing agents with fewer side effects

    Original URL path: http://stm.sciencemag.org/content/5/179 (2016-02-10)
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  • Table of Contents — April 10, 2013, 5 (180) | Science Translational Medicine
    2013 180ra48 EpCAM CTCs isolated from breast cancer patients express markers needed to promote brain metastasis Editor s Summary Abstract Full Text PDF Community Wide Isoniazid Preventive Therapy Drives Drug Resistant Tuberculosis A Model Based Analysis By Harriet L Mills Ted Cohen Caroline Colijn Science Translational Medicine 10 Apr 2013 180ra49 Community wide isoniazid preventive therapy may lead to long term rises in resistance at the population level Editor s Summary Abstract Full Text PDF Editors Choice Association Between Telomere Length and Disease More Evidence By Egle Bytautiene Science Translational Medicine 10 Apr 2013 180ec59 A genome wide meta analysis supports a causal association between telomere length and coronary artery disease Full Text Fixing Dendritic Spines in Fragile X By Christopher Gregg Science Translational Medicine 10 Apr 2013 180ec60 Inhibition of PAK a protein that regulates the actin cytoskeleton rescues the dendritic spine defect and behavioral abnormalities in a mouse model of fragile X syndrome Full Text In Search of a Functional Cure By Anandi N Sheth Science Translational Medicine 10 Apr 2013 180ec61 HIV infected adults who are able to control viral replication after therapy have small latent reservoirs in long living cells Full Text A Liquid Solution for Solid Tumors By Deepak Voora Science Translational Medicine 10 Apr 2013 180ec62 Circulating DNA is a superior predictor of tumor response to chemotherapy and survival Full Text Offering Guidance for Translation By Patrick Au Alexander M Bailey Science Translational Medicine 10 Apr 2013 180ec63 FDA recently released a draft guidance on the preclinical assessment of investigational cellular and gene therapy products Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit

    Original URL path: http://stm.sciencemag.org/content/5/180 (2016-02-10)
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  • Table of Contents — April 17, 2013, 5 (181) | Science Translational Medicine
    181cm4 Further progress in addressing noncommunicable diseases in low and middle income countries will require strengthening of both capacity and systems Abstract Full Text PDF Research Articles Development of a Prognostic Model for Breast Cancer Survival in an Open Challenge Environment By Wei Yi Cheng Tai Hsien Ou Yang Dimitris Anastassiou Science Translational Medicine 17 Apr 2013 181ra50 A computational modeling approach that combined several molecular features yielded a robust breast cancer prognostic model that was independently validated in a new patient data set Editor s Summary Abstract Full Text PDF HIV 1 Concentrations in Human Breast Milk Before and After Weaning By Louise Kuhn Hae Young Kim Jan Walter Donald M Thea Moses Sinkala Mwiya Mwiya Chipepo Kankasa Don Decker Grace M Aldrovandi Science Translational Medicine 17 Apr 2013 181ra51 Reducing the frequency of breast feeding during weaning and nonexclusive breast feeding boosts HIV 1 RNA and DNA concentrations in the breast milk of HIV infected women Editor s Summary Abstract Full Text PDF A Pyrrolo Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo By Yoriko Saito Hitomi Yuki Mitsuo Kuratani Yoshinobu Hashizume Shinsuke Takagi Teruki Honma Akiko Tanaka Mikako Shirouzu Junko Mikuni Noriko Handa Ikuko Ogahara Akiko Sone Yuho Najima Yuri Tomabechi Motoaki Wakiyama Naoyuki Uchida Mariko Tomizawa Murasawa Akiko Kaneko Satoshi Tanaka Nahoko Suzuki Hiroshi Kajita Yuki Aoki Osamu Ohara Leonard D Shultz Takehiro Fukami Toshio Goto Shuichi Taniguchi Shigeyuki Yokoyama Fumihiko Ishikawa Science Translational Medicine 17 Apr 2013 181ra52 A pyrrolo pyrimidine kinase inhibitor RK 20449 eliminates chemotherapy resistant human primary AML stem cells in vivo Editor s Summary Abstract Full Text PDF Editors Choice The Dendrimer SEALs Infiltrate Search and Destroy By Natalie Artzi Science Translational Medicine 17 Apr 2013 181ec64 Rational biomaterial design enables selective targeting and chemotherapeutic agent release to liver cells Full Text Microbes Hold the Key to Metformin Induced Longevity By Christopher R Polage Science Translational Medicine 17 Apr 2013 181ec65 Metformin induced alterations in microbial folate metabolism mediate life span extension in Caenorhabditis elegans Full Text H3 Minority Report By Anne Schaefer Science Translational Medicine 17 Apr 2013 181ec66 Histone H3 gain of function mutation paralyzes the histone methyltransferase Ezh2 in pediatric glioblastoma Full Text Border Security in the Lung Detail s at the Direction of CD1c Dendritic Cells By David A Zidar Science Translational Medicine 17 Apr 2013 181ec67 The CD1c subset of human dendritic cells direct epithelial retention of CD8 lymphocytes through TGF β mediated CD103 expression Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit About The Cover ONLINE COVER Doin It for Themselves and Future Generations A U S cultural icon Rosie the Riveter represents millions of American women who entered the workforce during World War II Rosies worked in factories of all kinds including some that manufactured munitions and other supplies needed for

    Original URL path: http://stm.sciencemag.org/content/5/181 (2016-02-10)
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  • Table of Contents — April 24, 2013, 5 (182) | Science Translational Medicine
    rare neurodevelopmental disorder Editor s Summary Abstract Full Text PDF T2 Magnetic Resonance Enables Nanoparticle Mediated Rapid Detection of Candidemia in Whole Blood By Lori A Neely Mark Audeh Nu Ai Phung Michael Min Adam Suchocki Daniella Plourde Matthew Blanco Vasiliki Demas Lynell R Skewis Theodora Anagnostou Jeffrey J Coleman Parris Wellman Eleftherios Mylonakis Thomas J Lowery Science Translational Medicine 24 Apr 2013 182ra54 Nanoparticles and T2 magnetic resonance allow for DNA amplification and detection of Candida species in clinical whole blood specimens Editor s Summary Abstract Full Text PDF Progesterone RANKL Is a Major Regulatory Axis in the Human Breast By Tamara Tanos George Sflomos Pablo C Echeverria Ayyakkannu Ayyanan Maria Gutierrez Jean Francois Delaloye Wassim Raffoul Maryse Fiche William Dougall Pascal Schneider Ozden Yalcin Ozuysal Cathrin Brisken Science Translational Medicine 24 Apr 2013 182ra55 Ex vivo model identifies the progesterone RANKL axis as an important proliferative stimulus in the human breast Editor s Summary Abstract Full Text PDF Editors Choice Uncovering a Hidden Talent By Margaret K Callahan Science Translational Medicine 24 Apr 2013 182ec68 Anthracycline chemotherapy activates an anticancer immune response Full Text A Cool Intervention for Posttraumatic Epilepsy By Tore Eid Science Translational Medicine 24 Apr 2013 182ec69 Mild passive focal cooling prevents epileptic seizures after head injury in rats Full Text A One Man Show Glioblastoma Constructs Its Own Niche By Cyrus M Ghajar Science Translational Medicine 24 Apr 2013 182ec70 Deadly brain tumors are able to generate components of their own microenvironment Full Text Is Pulmonary Arterial Hypertension a Cancer By Adriano R Tonelli Science Translational Medicine 24 Apr 2013 182ec71 Nutlin 3A a selective molecule that stabilizes p53 can induce pulmonary artery smooth muscle cell growth arrest preventing or reversing pulmonary hypertension in mouse models Full Text More From Science Translational Medicine Current

    Original URL path: http://stm.sciencemag.org/content/5/182 (2016-02-10)
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