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  • Table of Contents — August 28, 2013, 5 (200) | Science Translational Medicine
    A histone binding protein that declines with age in the human dentate gyrus can reverse age related memory deficits in mice Editor s Summary Abstract Full Text PDF Up Regulation of PD L1 IDO and T regs in the Melanoma Tumor Microenvironment Is Driven by CD8 T Cells By Stefani Spranger Robbert M Spaapen Yuanyuan Zha Jason Williams Yuru Meng Thanh T Ha Thomas F Gajewski Science Translational Medicine 28 Aug 2013 200ra116 CD8 T cells induce immunosuppressive mechanisms in the tumor microenvironment Editor s Summary Abstract Full Text PDF Blocking Macrophage Leukotriene B 4 Prevents Endothelial Injury and Reverses Pulmonary Hypertension By Wen Tian Xinguo Jiang Rasa Tamosiuniene Yon K Sung Jin Qian Gundeep Dhillon Lajos Gera Laszlo Farkas Marlene Rabinovitch Roham T Zamanian Mohammed Inayathullah Marina Fridlib Jayakumar Rajadas Marc Peters Golden Norbert F Voelkel Mark R Nicolls Science Translational Medicine 28 Aug 2013 200ra117 In a rat model of pulmonary hypertension inhibition of LTB 4 synthesis in macrophages that accumulate in lung tissue reverses the disease Editor s Summary Abstract Full Text PDF Editors Choice New MEK anisms for Targeted Therapies By Margaret K Callahan Science Translational Medicine 28 Aug 2013 200ec141 Mechanistic differences in how MEK inhibitors work may explain differences in sensitivity to therapy between BRAF and KRAS mutant tumors Full Text Starvation Strengthens Addiction By Tore Eid Science Translational Medicine 28 Aug 2013 200ec142 Food restriction enhances the addictive effect of cocaine via glutamate and dopamine mediated mechanisms in the brain Full Text Nothing but NET By Cyrus M Ghajar Science Translational Medicine 28 Aug 2013 200ec143 Extracellular traps released by neutrophils to fight infection may entrap circulating tumor cells and promote metastasis Full Text Estimation of Blood Flow Resistance in the Lung with MRI By Adriano R Tonelli Science Translational Medicine 28 Aug

    Original URL path: http://stm.sciencemag.org/content/5/200 (2016-02-10)
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  • Table of Contents — September 04, 2013, 5 (201) | Science Translational Medicine
    Summary Abstract Full Text PDF Rapid Label Free Detection of Brain Tumors with Stimulated Raman Scattering Microscopy By Minbiao Ji Daniel A Orringer Christian W Freudiger Shakti Ramkissoon Xiaohui Liu Darryl Lau Alexandra J Golby Isaiah Norton Marika Hayashi Nathalie Y R Agar Geoffrey S Young Cathie Spino Sandro Santagata Sandra Camelo Piragua Keith L Ligon Oren Sagher X Sunney Xie Science Translational Medicine 04 Sep 2013 201ra119 Stimulated Raman scattering microscopy provides a rapid label free means of detecting tumor infiltration of brain tissue ex vivo and in vivo Editor s Summary Abstract Full Text PDF Hedgehog Agonist Therapy Corrects Structural and Cognitive Deficits in a Down Syndrome Mouse Model By Ishita Das Joo Min Park Jung H Shin Soo Kyeong Jeon Hernan Lorenzi David J Linden Paul F Worley Roger H Reeves Science Translational Medicine 04 Sep 2013 201ra120 In a mouse model of Down syndrome treatment with a Sonic hedgehog agonist on the day of birth normalized cerebellar structure and improved learning and memory Editor s Summary Abstract Full Text PDF Editors Choice Surprisingly Easy to Swallow By William J Mack Science Translational Medicine 04 Sep 2013 201ec145 A straightforward dysphagia screening initiative led to an increase in patients tested and a decrease in hospital acquired pneumonia in the setting of acute stroke Full Text Seeing the Big Picture in Fragile X Syndrome By Vikaas S Sohal Science Translational Medicine 04 Sep 2013 201ec146 Measuring activity in many neurons at once reveals abnormal patterns of circuit activity in a mouse model of Fragile X syndrome Full Text Blood Sugar Food for Thought By Amir Tirosh Science Translational Medicine 04 Sep 2013 201ec147 Higher glucose concentrations may be a risk factor for dementia Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline

    Original URL path: http://stm.sciencemag.org/content/5/201 (2016-02-10)
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  • Table of Contents — September 11, 2013, 5 (202) | Science Translational Medicine
    Sumazin Mitchell C Benson Michael M Shen Andrea Califano Cory Abate Shen Science Translational Medicine 11 Sep 2013 202ra122 A three gene panel derived from mechanistic models of cell senescence predicts outcome of low Gleason score prostate tumors Editor s Summary Abstract Full Text PDF Down Regulation of Autophagy Related Protein 5 ATG5 Contributes to the Pathogenesis of Early Stage Cutaneous Melanoma By He Liu Zhaoyue He Thomas von Rütte Shida Yousefi Robert E Hunger Hans Uwe Simon Science Translational Medicine 11 Sep 2013 202ra123 Down regulation of autophagy related protein 5 decreases autophagy and contributes to tumorigenesis in human melanoma cells and patients tumors Editor s Summary Abstract Full Text PDF Editors Choice BAT Burns Fat Cool By Ania M Jastreboff Science Translational Medicine 11 Sep 2013 202ec148 Cold exposure activates brown adipose tissue in adult humans increasing nonshivering thermogenesis and energy expenditure while decreasing fat mass Full Text Co opting a Tumor Predator to Provide Life Support By Adam A Margolin Science Translational Medicine 11 Sep 2013 202ec149 Tumor cells acquire resistance to anti VEGF therapy by mobilizing immune cells through an IL 17 mediated paracrine signaling network Full Text Implantable Lanterns for Cancer Therapy By Erkin Seker Science Translational Medicine 11 Sep 2013 202ec150 Implantable illumination devices enable selective thermal and drug therapy of deep tumors Full Text The Virtue of Intolerance By Benjamin F Voight Science Translational Medicine 11 Sep 2013 202ec151 Ordering genes based on genetic variation at the population level helps to prioritize mutations that underlie human disease Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit About The Cover ONLINE COVER Dissecting DNA

    Original URL path: http://stm.sciencemag.org/content/5/202 (2016-02-10)
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  • Table of Contents — September 25, 2013, 5 (204) | Science Translational Medicine
    dermatitis patients express elevated antiviral proteins in lesional skin because of the T H 17 cytokine IL 29 Editor s Summary Abstract Full Text PDF Generation of Effector Memory T Cell Based Mucosal and Systemic Immunity with Pulmonary Nanoparticle Vaccination By Adrienne V Li James J Moon Wuhbet Abraham Heikyung Suh Jamal Elkhader Michael A Seidman Minmin Yen Eung Jun Im Maria H Foley Dan H Barouch Darrell J Irvine Science Translational Medicine 25 Sep 2013 204ra130 A lipid nanocapsule vaccine promotes cross presentation of antigen with enhanced draining lymph node delivery to elicit an effector memory CD8 T cell response Editor s Summary Abstract Full Text PDF siRNA Screen for Genes That Affect Junín Virus Entry Uncovers Voltage Gated Calcium Channels as a Therapeutic Target By Madakasira Lavanya Christian D Cuevas Monica Thomas Sara Cherry Susan R Ross Science Translational Medicine 25 Sep 2013 204ra131 Voltage gated calcium channel blockers may prevent fusion and cell entry of New World arenaviruses Editor s Summary Abstract Full Text PDF Use of Collateral Sensitivity Networks to Design Drug Cycling Protocols That Avoid Resistance Development By Lejla Imamovic Morten O A Sommer Science Translational Medicine 25 Sep 2013 204ra132 Elucidation of complex collateral sensitivity networks provides rationale for new sequential drug deployment strategies that restrain antibiotic resistance development Editor s Summary Abstract Full Text PDF Editors Choice Exercise Red Wine or Both By Egle Bytautiene Science Translational Medicine 25 Sep 2013 204ec157 Exercise not resveratrol enhances skeletal muscle function in aging mice Full Text Big Genes Cause Big Problems By Christopher Gregg Science Translational Medicine 25 Sep 2013 204ec158 Topoisomerases facilitate the transcription of long genes including many that contribute to autism spectrum disorders Full Text Gut Pathogens Freeloading Dinner Guests By Anandi N Sheth Science Translational Medicine 25 Sep 2013 204ec159 Increased

    Original URL path: http://stm.sciencemag.org/content/5/204 (2016-02-10)
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  • Table of Contents — October 02, 2013, 5 (205) | Science Translational Medicine
    2013 205ra135 An in vitro system can determine the pharmacokinetic drivers of antimalarial drug pharmacodynamics leading to more rationally developed new drug candidates Editor s Summary Abstract Full Text PDF Peripheral Blood Mononuclear Cell Gene Expression Profiles Predict Poor Outcome in Idiopathic Pulmonary Fibrosis By Jose D Herazo Maya Imre Noth Steven R Duncan SungHwan Kim Shwu Fan Ma George C Tseng Eleanor Feingold Brenda M Juan Guardela Thomas J Richards Yves Lussier Yong Huang Rekha Vij Kathleen O Lindell Jianmin Xue Kevin F Gibson Steven D Shapiro Joe G N Garcia Naftali Kaminski Science Translational Medicine 02 Oct 2013 205ra136 Genome scale transcriptomic profiling of peripheral blood mononuclear cells from patients with idiopathic pulmonary fibrosis reveals that decreased expression of CD28 ICOS LCK and ITK predicts mortality Editor s Summary Abstract Full Text PDF Review High Throughput Methods for Combinatorial Drug Discovery By Xiaochen Sun Santiago Vilar Nicholas P Tatonetti Science Translational Medicine 02 Oct 2013 205rv1 Combinatorial drug discovery will rely on new approaches to analyzing highly dimensional data resources Editor s Summary Abstract Full Text PDF Editors Choice Sticking with the Pattern for a Safer Glue By Natalie Artzi Science Translational Medicine 02 Oct 2013 205ec161 Surface micropatterning and reactive chemistry are used to develop adhesive materials with adequate adhesion and reduced toxicity Full Text Neutrophils Block Bacterial Flood in Gut Infection By Christopher R Polage Science Translational Medicine 02 Oct 2013 205ec162 Neutrophils form a protective cast around commensal bacteria to limit mucosal exposure during intestinal infections Full Text Length Matters By Anne Schaefer Science Translational Medicine 02 Oct 2013 205ec163 Reduced transcription of very long genes depends on the activity of topoisomerase enzymes that have been implicated in autism spectrum disorders Full Text B Lymphocytes Adding Insult to Injury After Myocardial Infarction By David A

    Original URL path: http://stm.sciencemag.org/content/5/205 (2016-02-10)
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  • Table of Contents — October 09, 2013, 5 (206) | Science Translational Medicine
    infected mice thus preventing neurodegeneration and clinical disease Editor s Summary Abstract Full Text PDF BPIFB1 Is a Lung Specific Autoantigen Associated with Interstitial Lung Disease By Anthony K Shum Mohammad Alimohammadi Catherine L Tan Mickie H Cheng Todd C Metzger Christopher S Law Wint Lwin Jaakko Perheentupa Helene Bour Jordan Jean Claude Carel Eystein S Husebye Filippo De Luca Christer Janson Ravishankar Sargur Noémie Dubois Merja Kajosaari Paul J Wolters Harold A Chapman Olle Kämpe Mark S Anderson Science Translational Medicine 09 Oct 2013 206ra139 Autoimmunity targeting the lung specific antigen BPIFB1 may be important to the pathogenesis of interstitial lung disease Editor s Summary Abstract Full Text PDF Systems Pharmacology of Adverse Event Mitigation by Drug Combinations By Shan Zhao Tomohiro Nishimura Yibang Chen Evren U Azeloglu Omri Gottesman Chiara Giannarelli Mohammad U Zafar Ludovic Benard Juan J Badimon Roger J Hajjar Joseph Goldfarb Ravi Iyengar Science Translational Medicine 09 Oct 2013 206ra140 Drug combinations that mitigate adverse events were identified using the FDA Adverse Event Reporting System and one combination exenatide and rosiglitazone was tested in a rodent model Editor s Summary Abstract Full Text PDF Editors Choice EGFR Mutations Transform Tumors Inside and Out By Margaret K Callahan Science Translational Medicine 09 Oct 2013 206ec165 EGFR mutant tumors are associated with an immunosuppressive tumor microenvironment and are susceptible to PD 1 blockade Full Text A One Two Punch for Aging and Brain Malformations By Tore Eid Science Translational Medicine 09 Oct 2013 206ec166 Maternally inherited and somatic mitochondrial DNA mutations additively contribute to human dysfunction and disease Full Text Creating Refuge By Cyrus M Ghajar Science Translational Medicine 09 Oct 2013 206ec167 EGF receptor inhibition causes lung cancer cells to make fibronectin which in turn promotes therapeutic resistance Full Text A Reflex Cause of Pulmonary Hypertension

    Original URL path: http://stm.sciencemag.org/content/5/206 (2016-02-10)
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  • Table of Contents — October 16, 2013, 5 (207) | Science Translational Medicine
    Erhe Gao Muniswamy Madesh Thomas Force Science Translational Medicine 16 Oct 2013 207ra141 Blocking the activity of a cardiomyocyte specific protein kinase with a small molecule inhibitor reduces oxidative stress myocyte death and adverse remodeling in the ischemic heart Editor s Summary Abstract Full Text PDF A Blood Based Proteomic Classifier for the Molecular Characterization of Pulmonary Nodules By Xiao jun Li Clive Hayward Pui Yee Fong Michel Dominguez Stephen W Hunsucker Lik Wee Lee Matthew McLean Scott Law Heather Butler Michael Schirm Olivier Gingras Julie Lamontagne Rene Allard Daniel Chelsky Nathan D Price Stephen Lam Pierre P Massion Harvey Pass William N Rom Anil Vachani Kenneth C Fang Leroy Hood Paul Kearney Science Translational Medicine 16 Oct 2013 207ra142 Systems biology and targeted mass spectrometry were combined to develop and validate a blood based protein classifier for pulmonary nodules Editor s Summary Abstract Full Text PDF mAbs and Ad Vectored IFN α Therapy Rescue Ebola Infected Nonhuman Primates When Administered After the Detection of Viremia and Symptoms By Xiangguo Qiu Gary Wong Lisa Fernando Jonathan Audet Alexander Bello Jim Strong Judie B Alimonti Gary P Kobinger Science Translational Medicine 16 Oct 2013 207ra143 Monoclonal antibodies and adenovirus vectored IFN α extend the treatment window for Zaire ebolavirus in macaques Editor s Summary Abstract Full Text PDF Tumor Specific Activation of an EGFR Targeting Probody Enhances Therapeutic Index By Luc R Desnoyers Olga Vasiljeva Jennifer H Richardson Annie Yang Elizabeth E M Menendez Tony W Liang Chihunt Wong Paul H Bessette Kathy Kamath Stephen J Moore Jason G Sagert Daniel R Hostetter Fei Han Jason Gee Jeanne Flandez Kate Markham Margaret Nguyen Michael Krimm Kenneth R Wong Shouchun Liu Patrick S Daugherty James W West Henry B Lowman Science Translational Medicine 16 Oct 2013 207ra144 A proteolytically activatable EGFR Probody demonstrates antitumor efficacy while alleviating toxicity Editor s Summary Abstract Full Text PDF Editors Choice Looking into the Crystal Ball for Alzheimer s Disease By William J Mack Science Translational Medicine 16 Oct 2013 207ec169 Markers may detect early vascular dysfunction in patients at risk for Alzheimer s disease Full Text An Anti Depressing Discovery for Lung Cancer Treatment By Trudy G Oliver Science Translational Medicine 16 Oct 2013 207ec170 A drug repurposing strategy identifies tricyclic antidepressants as FDA approved compounds that combat the growth of small cell lung cancer and other neuroendocrine tumors Full Text Sense and Sensibility of Insulin Pumps By Amir Tirosh Science Translational Medicine 16 Oct 2013 207ec171 The insulin pump had a positive impact on type 1 diabetes patients telling the pump when to stop might do the same Full Text Serotonin Gives Oxytocin a Helping Hand By Vikaas S Sohal Science Translational Medicine 16 Oct 2013 207ec172 Oxytocin modulates the rewarding effects of social interaction by acting on serotonin release and synaptic plasticity in the nucleus accumbens Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial

    Original URL path: http://stm.sciencemag.org/content/5/207 (2016-02-10)
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  • Table of Contents — October 23, 2013, 5 (208) | Science Translational Medicine
    208ra146 Stimulating the midbrain improves gait and locomotion in rats with chronic spinal cord injury Editor s Summary Abstract Full Text PDF Major Cancer Regressions in Mesothelioma After Treatment with an Anti Mesothelin Immunotoxin and Immune Suppression By Raffit Hassan Andrew C Miller Elad Sharon Anish Thomas James C Reynolds Alexander Ling Robert J Kreitman Markku M Miettinen Seth M Steinberg Daniel H Fowler Ira Pastan Science Translational Medicine 23 Oct 2013 208ra147 In patients with advanced chemotherapy refractory mesothelioma treatment with the anti mesothelin immunotoxin SS1P and immunosuppression with pentostatin and cyclophosphamide resulted in marked and durable tumor regressions Editor s Summary Abstract Full Text PDF Slow Wave Activity Saturation and Thalamocortical Isolation During Propofol Anesthesia in Humans By Róisín Ní Mhuircheartaigh Catherine Warnaby Richard Rogers Saad Jbabdi Irene Tracey Science Translational Medicine 23 Oct 2013 208ra148 In subjects treated with an anesthetic saturation of slow wave activity in the EEG indicates the onset of thalamocortical isolation from the external world Editor s Summary Abstract Full Text PDF Targeting RNA Foci in iPSC Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion By Dhruv Sareen Jacqueline G O Rourke Pratap Meera A K M G Muhammad Sharday Grant Megan Simpkinson Shaughn Bell Sharon Carmona Loren Ornelas Anais Sahabian Tania Gendron Leonard Petrucelli Michael Baughn John Ravits Matthew B Harms Frank Rigo C Frank Bennett Thomas S Otis Clive N Svendsen Robert H Baloh Science Translational Medicine 23 Oct 2013 208ra149 Antisense oligonucleotides can correct disease specific phenotypes in cultured motor neurons differentiated from iPSCs derived from ALS patients with a C9ORF72 repeat expansion Editor s Summary Abstract Full Text PDF Editors Choice Oxytocin Curbs Cookie Consumption By Ania M Jastreboff Science Translational Medicine 23 Oct 2013 208ec173 Intranasal oxytocin administration decreases reward based food consumption in humans

    Original URL path: http://stm.sciencemag.org/content/5/208 (2016-02-10)
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