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  • Table of Contents — October 30, 2013, 5 (209) | Science Translational Medicine
    Jennifer van Eyk Antony Rosen Felipe Andrade Science Translational Medicine 30 Oct 2013 209ra150 RA associated hypercitrullination is specifically induced by immune mediated membrane pore forming pathways Editor s Summary Abstract Full Text PDF Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents Monkeys and Humans By Brian Finan Tao Ma Nickki Ottaway Timo D Müller Kirk M Habegger Kristy M Heppner Henriette Kirchner Jenna Holland Jazzminn Hembree Christine Raver Sarah H Lockie David L Smiley Vasily Gelfanov Bin Yang Susanna Hofmann Dennis Bruemmer Daniel J Drucker Paul T Pfluger Diego Perez Tilve Jaswant Gidda Louis Vignati Lianshan Zhang Jonathan B Hauptman Michele Lau Mathieu Brecheisen Sabine Uhles William Riboulet Emmanuelle Hainaut Elena Sebokova Karin Conde Knape Anish Konkar Richard D DiMarchi Matthias H Tschöp Science Translational Medicine 30 Oct 2013 209ra151 Compared to best in class GLP 1 mono agonists unimolecular co agonists of GLP 1 and GIP with optimized pharmacokinetics enhance glycemic and metabolic benefits in mammals Editor s Summary Abstract Full Text PDF Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi Based Therapy for Glioblastoma By Samuel A Jensen Emily S Day Caroline H Ko Lisa A Hurley Janina P Luciano Fotini M Kouri Timothy J Merkel Andrea J Luthi Pinal C Patel Joshua I Cutler Weston L Daniel Alexander W Scott Matthew W Rotz Thomas J Meade David A Giljohann Chad A Mirkin Alexander H Stegh Science Translational Medicine 30 Oct 2013 209ra152 siRNA based spherical nucleic acid SNA nanoparticle conjugates silence antiapoptosis signaling and impair GBM progression Editor s Summary Abstract Full Text PDF A Genomics Based Classification of Human Lung Tumors By The Clinical Lung Cancer Genome Project CLCGP and Network Genomic Medicine NGM Science Translational Medicine 30 Oct 2013 209ra153 The pattern of mutations in human lung cancer differs by tumor subtype and is a useful addition to histology for selecting targeted therapy and improving patient survival Editor s Summary Abstract Full Text PDF Editors Choice An Aneurysm Model to Help Predict the Unpredictable By Mercedes Balcells Science Translational Medicine 30 Oct 2013 209ec176 A porcine model of thoracic aortic aneurysm closely recapitulates the clinical hallmarks of this disease Full Text One Device to Find Them All By Edward Kai Hua Chow Science Translational Medicine 30 Oct 2013 209ec177 Graphene oxide nanosheets in a microfluidic device integrate both isolation and analysis steps for tracking circulating tumor cells Full Text Foiling Inflammatory Bowel Disease By Mustafa Mahfuz Science Translational Medicine 30 Oct 2013 209ec178 Aluminum enhances intestinal inflammation in a mouse model Full Text Out with the New In with the Old By Goutham Narla Science Translational Medicine 30 Oct 2013 209ec179 Computational 21st century techniques pinpoint tricyclic antidepressants discovered in the 1950s as possible cancer therapeutics Full Text Pitfalls in Identifying Causal Mutations for Disease By Benjamin M Neale Science Translational Medicine 30 Oct 2013 209ec180 Current methods for determining deleterious mutations even for known variants in well established genes need validation to confirm the phenotypic effects Full Text More From Science Translational Medicine

    Original URL path: http://stm.sciencemag.org/content/5/209 (2016-02-10)
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  • Table of Contents — November 06, 2013, 5 (210) | Science Translational Medicine
    Ifft Solaiman Shokur Zheng Li Mikhail A Lebedev Miguel A L Nicolelis Science Translational Medicine 06 Nov 2013 210ra154 Large scale recordings from monkey cortex enabled simultaneous control of two avatar arms through a brain machine interface Editor s Summary Abstract Full Text PDF A Microchannel Neuroprosthesis for Bladder Control After Spinal Cord Injury in Rat By Daniel J Chew Lan Zhu Evangelos Delivopoulos Ivan R Minev Katherine M Musick Charles A Mosse Michael Craggs Nicholas Donaldson Stéphanie P Lacour Stephen B McMahon James W Fawcett Science Translational Medicine 06 Nov 2013 210ra155 An electronic interface for recording and stimulating nerves that innervate the bladder helps to restore normal bladder function in rats with spinal cord injury Editor s Summary Abstract Full Text PDF Editors Choice Money for Robots By Kelly LaMarco Science Translational Medicine 06 Nov 2013 210ec181 Co robots might be our new best friends if a U S federal funding initiative is successful Full Text Graph Theory Modeling for Diagnosing Presymptomatic Alzheimer s Disease By Egle Bytautiene Science Translational Medicine 06 Nov 2013 210ec182 Graph theory modeling of brain MRI images reveals early presymptomatic signs of Alzheimer s disease Full Text Targeting ER Stress in Parkinson s Disease By Christopher Gregg Science Translational Medicine 06 Nov 2013 210ec183 α Synuclein mediated toxicity in Parkinson s disease involves nitrosative stress endoplasmic reticulum ER stress and impaired ER function which can be rescued in vitro with a small molecule Full Text A Chance of a Cure for HIV By Anandi N Sheth Science Translational Medicine 06 Nov 2013 210ec184 In an HIV infected infant who received antiretroviral therapy from 30 hours until 18 months of age HIV virus was undetectable months after therapy was stopped Full Text Silencing the Sounds of Hypertrophic Cardiomyopathy By Deepak Voora Science Translational Medicine

    Original URL path: http://stm.sciencemag.org/content/5/210 (2016-02-10)
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  • Table of Contents — November 13, 2013, 5 (211) | Science Translational Medicine
    insulin producing pancreatic β cells in type 1 diabetes requires an intact UPR and treatment with tauroursodeoxycholic acid can restore UPR defects Editor s Summary Abstract Full Text PDF Aldehyde Dehydrogenase Expression Drives Human Regulatory T Cell Resistance to Posttransplantation Cyclophosphamide By Christopher G Kanakry Sudipto Ganguly Marianna Zahurak Javier Bolaños Meade Christopher Thoburn Brandy Perkins Ephraim J Fuchs Richard J Jones Allan D Hess Leo Luznik Science Translational Medicine 13 Nov 2013 211ra157 Regulatory T cells become resistant to cyclophosphamide after allogeneic stimulation protecting against GVHD Editor s Summary Abstract Full Text PDF Sclerostin Inhibition Reverses Skeletal Fragility in an Lrp5 Deficient Mouse Model of OPPG Syndrome By Rajendra Kedlaya Shreya Veera Daniel J Horan Rachel E Moss Ugur M Ayturk Christina M Jacobsen Margot E Bowen Chris Paszty Matthew L Warman Alexander G Robling Science Translational Medicine 13 Nov 2013 211ra158 Humans with osteoporosis pseudoglioma syndrome might benefit from sclerostin neutralization therapies Editor s Summary Abstract Full Text PDF SUMO 1 Gene Transfer Improves Cardiac Function in a Large Animal Model of Heart Failure By Lisa Tilemann Ahyoung Lee Kiyotake Ishikawa Jaume Aguero Kleopatra Rapti Carlos Santos Gallego Erik Kohlbrenner Kenneth M Fish Changwon Kho Roger J Hajjar Science Translational Medicine 13 Nov 2013 211ra159 Cardiac gene delivery of small ubiquitin related modifier 1 SUMO 1 improved cardiac function and stabilized left ventricular volumes in a swine model of ischemic heart failure Editor s Summary Abstract Full Text PDF Editors Choice Trojan siRNA Opens the Door to Chemotherapy By Natalie Artzi Science Translational Medicine 13 Nov 2013 211ec186 A layer by layer nanoparticle assembly allows timed combination therapy against triple negative breast cancer in mice Full Text It Takes Two to Make a RAF Signal Right By Adam A Margolin Science Translational Medicine 13 Nov 2013 211ec187 A new technology allows single molecule resolution imaging of RAS multimer formation Full Text The Gut Is No Place for Freedom of Expression By Christopher R Polage Science Translational Medicine 13 Nov 2013 211ec188 Histone deacetylase 3 regulates epithelial cell responses to bacteria in the gut Full Text The Philosopher s Stone of Reprogramming By Anne Schaefer Science Translational Medicine 13 Nov 2013 211ec189 A hierarchical transcriptional mechanism governs direct conversion of mouse embryonic fibroblasts to neurons Full Text Newer Generation Drug Eluting Stents Heal Thyself By David A Zidar Science Translational Medicine 13 Nov 2013 211ec190 Newer generation drug eluting stents are associated with improved re endothelialization and less inflammation in patients Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit About The Cover ONLINE COVER Make No Bones About It Shown is an undemineralized transverse tissue section through the mid proximal femur of a 16 week old mouse that had been administered a series of bone seeking fluorochrome labels at different times prior to sacrifice calcein green given at

    Original URL path: http://stm.sciencemag.org/content/5/211 (2016-02-10)
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  • Table of Contents — November 27, 2013, 5 (213) | Science Translational Medicine
    in vivo Editor s Summary Abstract Full Text PDF Real Time Aptamer Based Tracking of Circulating Therapeutic Agents in Living Animals By Brian Scott Ferguson David A Hoggarth Dan Maliniak Kyle Ploense Ryan J White Nick Woodward Kuangwen Hsieh Andrew J Bonham Michael Eisenstein Tod E Kippin Kevin W Plaxco Hyongsok Tom Soh Science Translational Medicine 27 Nov 2013 213ra165 An aptamer based biosensor continuously measures the concentration of drug molecules in the blood of living animals and in patient samples Editor s Summary Abstract Full Text PDF The Tongue Enables Computer and Wheelchair Control for People with Spinal Cord Injury By Jeonghee Kim Hangue Park Joy Bruce Erica Sutton Diane Rowles Deborah Pucci Jaimee Holbrook Julia Minocha Beatrice Nardone Dennis West Anne Laumann Eliot Roth Mike Jones Emir Veledar Maysam Ghovanloo Science Translational Medicine 27 Nov 2013 213ra166 Individuals with severe spinal cord injury control a computer and powered wheelchair by using a wireless tongue operated assistive technology called the Tongue Drive System Editor s Summary Abstract Full Text PDF Transepithelial Transport of Fc Targeted Nanoparticles by the Neonatal Fc Receptor for Oral Delivery By Eric M Pridgen Frank Alexis Timothy T Kuo Etgar Levy Nissenbaum Rohit Karnik Richard S Blumberg Robert Langer Omid C Farokhzad Science Translational Medicine 27 Nov 2013 213ra167 Nanoparticles targeted to the neonatal Fc receptor cross the intestinal epithelium and reach systemic circulation after oral administration Editor s Summary Abstract Full Text PDF Editors Choice Stenting for Stroke By William J Mack Science Translational Medicine 27 Nov 2013 213ec195 Aggressive medical management demonstrates benefit over stenting for high risk patients with intracranial stenosis Full Text Waking a Sleeping Giant on Purpose By Trudy G Oliver Science Translational Medicine 27 Nov 2013 213ec196 Rousing and treating dormant tumors before their escape from the innate immune

    Original URL path: http://stm.sciencemag.org/content/5/213 (2016-02-10)
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  • Table of Contents — December 04, 2013, 5 (214) | Science Translational Medicine
    Thomas Dick Paul W Smith Thierry T Diagana Ujjini H Manjunatha Science Translational Medicine 04 Dec 2013 214ra168 The small molecule indolcarboxamide is a potential drug candidate for treating multidrug resistant tuberculosis Editor s Summary Abstract Full Text PDF Digital Genomic Quantification of Tumor Infiltrating Lymphocytes By Harlan S Robins Nolan G Ericson Jamie Guenthoer Kathy C O Briant Muneesh Tewari Charles W Drescher Jason H Bielas Science Translational Medicine 04 Dec 2013 214ra169 A digital DNA based assay demonstrates an association between higher TIL counts and improved survival among women with ovarian cancer Editor s Summary Abstract Full Text PDF Microfluidic CD4 and CD8 T Lymphocyte Counters for Point of Care HIV Diagnostics Using Whole Blood By Nicholas N Watkins Umer Hassan Gregory Damhorst HengKan Ni Awais Vaid William Rodriguez Rashid Bashir Science Translational Medicine 04 Dec 2013 214ra170 A microfluidic biochip enumerates CD4 or CD8 T lymphocytes in whole blood of healthy and HIV infected donors Editor s Summary Abstract Full Text PDF Minimal Residual Disease Monitoring with High Throughput Sequencing of T Cell Receptors in Cutaneous T Cell Lymphoma By Wen Kai Weng Randall Armstrong Sally Arai Cindy Desmarais Richard Hoppe Youn H Kim Science Translational Medicine 04 Dec 2013 214ra171 TCRB high throughput sequencing can monitor response to therapy in a skin lymphoma patient population Editor s Summary Abstract Full Text PDF Editors Choice Diabetes Shrinks the Brain By Ania M Jastreboff Science Translational Medicine 04 Dec 2013 214ec199 Type 2 diabetes is associated with loss of brain volume and cognitive deficits Full Text Oncogenic Driver Mutations Neither Tissue Specific nor Independent By Adam A Margolin Science Translational Medicine 04 Dec 2013 214ec200 Genomic analysis of 12 cancers identifies common somatic mutations across tumor types Full Text Finding the Proverbial Needle By Erkin Seker Science Translational

    Original URL path: http://stm.sciencemag.org/content/5/214 (2016-02-10)
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  • Table of Contents — December 11, 2013, 5 (215) | Science Translational Medicine
    Receptors iCARs Divert Off Target Immunotherapy Responses By Victor D Fedorov Maria Themeli Michel Sadelain Science Translational Medicine 11 Dec 2013 215ra172 Human T cells that are reversibly inhibited upon contact with antigen protect bystander tissues from immune destruction Editor s Summary Abstract Full Text PDF Dietary Therapy Mitigates Persistent Wake Deficits Caused by Mild Traumatic Brain Injury By Miranda M Lim Jaclynn Elkind Guoxiang Xiong Ray Galante Jingxu Zhu Lin Zhang Jie Lian Julianna Rodin Nicholas N Kuzma Allan I Pack Akiva S Cohen Science Translational Medicine 11 Dec 2013 215ra173 Mild traumatic brain injury causes persistent deficits in wakefulness in mice which are mitigated by a dietary therapy containing branched chain amino acids Editor s Summary Abstract Full Text PDF CD4 T Cells from IPEX Patients Convert into Functional and Stable Regulatory T Cells by FOXP3 Gene Transfer By Laura Passerini Eva Rossi Mel Claudia Sartirana Georgia Fousteri Attilio Bondanza Luigi Naldini Maria Grazia Roncarolo Rosa Bacchetta Science Translational Medicine 11 Dec 2013 215ra174 FOXP3 gene transfer in FOXP3 mutated CD4 T cells is feasible and converts IPEX conventional T cells into regulatory T cells Editor s Summary Abstract Full Text PDF Editors Choice Two Proteins One Stone By Mercedes Balcells Science Translational Medicine 11 Dec 2013 215ec203 Regulation of a single gene mediates recovery from spinal cord injury by optimizing counteracting effectors of axon growth Full Text Building Inner Strength By Edward Kai Hua Chow Science Translational Medicine 11 Dec 2013 215ec204 Transdermal drug delivery is enhanced by nanoparticle reinforced dissolving microneedles Full Text A New Kid on the Block By Goutham Narla Science Translational Medicine 11 Dec 2013 215ec205 Oncogenic and drug sensitive rearrangements in the NTRK1 gene are found in some lung cancers Full Text Harvesting HLA Region for Multiple Sclerosis Effects By Benjamin M

    Original URL path: http://stm.sciencemag.org/content/5/215 (2016-02-10)
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  • Table of Contents — January 01, 2014, 6 (217) | Science Translational Medicine
    Academia and Big Pharma United By Hans Gustaf Ljunggren Science Translational Medicine 01 Jan 2014 217ed1 Sweden s premier medical university the Karolinska Institutet and the big pharma AstraZeneca have established an integrated cardio metabolic research center with academic and pharma scientists working side by side Full Text PDF Research Articles The Circulating Proteinase Inhibitor α 1 Antitrypsin Regulates Neutrophil Degranulation and Autoimmunity By David A Bergin Emer P Reeves Killian Hurley Rebecca Wolfe Ramia Jameel Sean Fitzgerald Noel G McElvaney Science Translational Medicine 01 Jan 2014 217ra1 α 1 antitrypsin regulates neutrophil driven autoimmunity Editor s Summary Abstract Full Text PDF Silencing HoxA1 by Intraductal Injection of siRNA Lipidoid Nanoparticles Prevents Mammary Tumor Progression in Mice By Amy Brock Silva Krause Hu Li Marek Kowalski Michael S Goldberg James J Collins Donald E Ingber Science Translational Medicine 01 Jan 2014 217ra2 Silencing of HoxA1 with nanoparticle siRNA prevented loss of hormone receptor expression suppressed cell proliferation and reduced mammary tumor incidence in mice Editor s Summary Abstract Full Text PDF Genetic Engineering of Hematopoiesis for Targeted IFN α Delivery Inhibits Breast Cancer Progression By Giulia Escobar Davide Moi Anna Ranghetti Pinar Ozkal Baydin Mario Leonardo Squadrito Anna Kajaste Rudnitski Attilio Bondanza Bernhard Gentner Michele De Palma Roberta Mazzieri Luigi Naldini Science Translational Medicine 01 Jan 2014 217ra3 Inhibition of primary and metastatic breast cancer by targeted delivery of interferon α by tumor infiltrating monocytes Editor s Summary Abstract Full Text PDF More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit About The Cover ONLINE COVER Immunotherapy Hits the Mark Tumor immunotherapy is a promising new strategy for cancer treatment but is

    Original URL path: http://stm.sciencemag.org/content/6/217 (2016-02-10)
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  • Table of Contents — January 08, 2014, 6 (218) | Science Translational Medicine
    migraine attacks information provided to patients from negative to neutral to positive modified placebo and medication outcomes in a progressive fashion Editor s Summary Abstract Full Text PDF A Blood Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects By Nora Lang Maria J Pereira Yuhan Lee Ingeborg Friehs Nikolay V Vasilyev Eric N Feins Klemens Ablasser Eoin D O Cearbhaill Chenjie Xu Assunta Fabozzo Robert Padera Steve Wasserman Franz Freudenthal Lino S Ferreira Robert Langer Jeffrey M Karp Pedro J del Nido Science Translational Medicine 08 Jan 2014 218ra6 A light activated biodegradable adhesive seals cardiovascular defects in the presence of blood flow and could be useful during minimally invasive surgery Editor s Summary Abstract Full Text PDF Editors Choice Nanospherical Scouts on the Lookout for Circulating Tumor Cells By Natalie Artzi Science Translational Medicine 08 Jan 2014 218ec4 A layer by layer magnetic nanoparticle assembly allows rapid and selective detection of circulating cancer cells Full Text Oncogene Addiction How Cells Handle the Habit By Margaret K Callahan Science Translational Medicine 08 Jan 2014 218ec5 A growth hormone mediated negative feedback loop can explain why CML cells are so addicted to the BCR ABL oncogene Full Text Treating the Brain Through the Gut By Tore Eid Science Translational Medicine 08 Jan 2014 218ec6 Altering the gut microbiota alleviates signs of autism in a mouse model of the disorder Full Text Hold the Sugar By Cyrus M Ghajar Science Translational Medicine 08 Jan 2014 218ec7 Aberrant glucose metabolism may be the cause not just a consequence of the malignant phenotype Full Text Linking Autoimmunity and Pulmonary Arterial Hypertension By Adriano R Tonelli Science Translational Medicine 08 Jan 2014 218ec8 Type I interferon mediates pulmonary arterial hypertension by up regulating molecules responsible for vasoconstriction endothelial dysfunction and smooth

    Original URL path: http://stm.sciencemag.org/content/6/218 (2016-02-10)
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