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  • Table of Contents — March 19, 2014, 6 (228) | Science Translational Medicine
    Arash Rafii Viia Valge Archer Franck Pagès Michael R Speicher Jérôme Galon Science Translational Medicine 19 Mar 2014 228ra37 Genomic alterations result in changes of immune cell densities within the tumor Editor s Summary Abstract Full Text PDF Polyfunctional Fc Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines By Amy W Chung Musie Ghebremichael Hannah Robinson Eric Brown Ickwon Choi Sophie Lane Anne Sophie Dugast Matthew K Schoen Morgane Rolland Todd J Suscovich Alison E Mahan Larry Liao Hendrik Streeck Charla Andrews Supachai Rerks Ngarm Sorachai Nitayaphan Mark S de Souza Jaranit Kaewkungwal Punnee Pitisuttithum Donald Francis Nelson L Michael Jerome H Kim Chris Bailey Kellogg Margaret E Ackerman Galit Alter Science Translational Medicine 19 Mar 2014 228ra38 RV144 vaccination induced polyfunctional antibody Fc effector responses whereas VAX003 vaccination increased inhibitory IgG4 antibodies Editor s Summary Abstract Full Text PDF Vaccine Induced Env V1 V2 IgG3 Correlates with Lower HIV 1 Infection Risk and Declines Soon After Vaccination By Nicole L Yates Hua Xin Liao Youyi Fong Allan deCamp Nathan A Vandergrift William T Williams S Munir Alam Guido Ferrari Zhi yong Yang Kelly E Seaton Phillip W Berman Michael D Alpert David T Evans Robert J O Connell Donald Francis Faruk Sinangil Carter Lee Sorachai Nitayaphan Supachai Rerks Ngarm Jaranit Kaewkungwal Punnee Pitisuttithum James Tartaglia Abraham Pinter Susan Zolla Pazner Peter B Gilbert Gary J Nabel Nelson L Michael Jerome H Kim David C Montefiori Barton F Haynes Georgia D Tomaras Science Translational Medicine 19 Mar 2014 228ra39 A V1 V2 IgG3 response to HIV correlates with a decreased risk of HIV 1 infection and is one vaccine induced humoral response that is higher in a clinical trial showing HIV 1 vaccine efficacy compared to a trial showing nonefficacy Editor s Summary Abstract Full Text PDF Editors Choice Genetic Basis for Variations in the Effect of Physical Activity on Cardiometabolic Risk By Egle Bytautiene Science Translational Medicine 19 Mar 2014 228ec48 Negative effects of PPARA H 23 haplotype on individual cardiometabolic risk are attenuated by physical activity Full Text High Steaks for Cancer and Aging By Christopher Gregg Science Translational Medicine 19 Mar 2014 228ec49 A new study reveals that protein intake influences cancer risk diabetes and mortality during aging Full Text Knocking Out HIV Infection By Anandi N Sheth Science Translational Medicine 19 Mar 2014 228ec50 Infusion of HIV infected patients own immune cells after genetic alteration was safe and made the cells more resistant to HIV infection Full Text The Last Line of Defense Against Atherosclerosis By Deepak Voora Science Translational Medicine 19 Mar 2014 228ec51 The miRNA miR 126 protects against atherosclerosis by promoting a healthy endothelium Full Text Letter Author Response to Comment on Power of Rare Diseases Found in Translation By Mark C Fishman Science Translational Medicine 19 Mar 2014 228lr1 The study of rare diseases in both academic and industry settings yields new knowledge about human pathophysiology and ultimately helps patients Abstract Full Text PDF More From Science Translational

    Original URL path: http://stm.sciencemag.org/content/6/228 (2016-02-10)
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  • Table of Contents — March 26, 2014, 6 (229) | Science Translational Medicine
    R Nayak Yuanxin Xi Shiming Jiang Jason P Garee Dean P Edwards Adrian V Lee Jian Chen Martin J Shea Richard J Santen Frank Gannon Sara Kangaspeska Jaroslav Jelinek Jean Pierre J Issa Jennifer K Richer Anthony Elias Marie McIlroy Leonie S Young Nancy E Davidson Rachel Schiff Wei Li Steffi Oesterreich Science Translational Medicine 26 Mar 2014 229ra41 Genome wide screen identifies methylation of the estrogen repressed HOXC10 gene as a determinant of resistance to aromatase inhibitors in breast cancer Editor s Summary Abstract Full Text PDF DNA Repair Pathway Gene Expression Score Correlates with Repair Proficiency and Tumor Sensitivity to Chemotherapy By Sean P Pitroda Itai M Pashtan Hillary L Logan Brian Budke Thomas E Darga Ralph R Weichselbaum Philip P Connell Science Translational Medicine 26 Mar 2014 229ra42 Measuring DNA repair pathway choice determines the sensitivity of cancers to individual classes of treatment Editor s Summary Abstract Full Text PDF Cytotoxicity of Paclitaxel in Breast Cancer Is due to Chromosome Missegregation on Multipolar Spindles By Lauren M Zasadil Kristen A Andersen Dabin Yeum Gabrielle B Rocque Lee G Wilke Amye J Tevaarwerk Ronald T Raines Mark E Burkard Beth A Weaver Science Translational Medicine 26 Mar 2014 229ra43 The chemotherapy drug paclitaxel causes tumor regression and cell death by inducing high rates of chromosome missegregation on multipolar spindles Editor s Summary Abstract Full Text PDF Editors Choice No Nukes A New Way to Treat Hepatitis B By Simon W Beaven Science Translational Medicine 26 Mar 2014 229ec52 A combination therapy might cure hepatitis B infection by obliterating latent nuclear viral DNA Full Text Getting to the Heart of Consciousness By Chester L Drum Science Translational Medicine 26 Mar 2014 229ec53 Neocortical brain responses to individual heartbeats predict a subject s ability to cognitively identify a visual stimulus Full Text Spotlight on Cancer By Kara L Spiller Science Translational Medicine 26 Mar 2014 229ec54 Activatable immunoconjugates targeting cancer cells can be used to image and treat disseminated micrometastases Full Text Intelligent Vaccine Design Evolution of a Principle By Jie Sun Science Translational Medicine 26 Mar 2014 229ec55 Epitope focused artificial immunogens offer hope for a safe RSV vaccine Full Text Monkeying Around with the Genome By Paul J Tesar Science Translational Medicine 26 Mar 2014 229ec56 TALEN gene editing disrupts Mepc2 in nonhuman primates Full Text Letters Comment on Drug Discovery Turning the Titanic By W Joost Lesterhuis Anthony Bosco Richard A Lake Science Translational Medicine 26 Mar 2014 229le2 Molecular and cellular events that govern a disease resolution may pinpoint new druggable pathways Abstract Full Text PDF Author Response to Comment on Drug Discovery Turning the Titanic By Elias A Zerhouni Science Translational Medicine 26 Mar 2014 229lr2 In the face of poorly understood disease complexity a diversity of approaches is the best strategy Abstract Full Text PDF More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors

    Original URL path: http://stm.sciencemag.org/content/6/229 (2016-02-10)
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  • Table of Contents — April 02, 2014, 6 (230) | Science Translational Medicine
    Helper Cells in Inflamed Human Renal Tissue By Vladimir M Liarski Natalya Kaverina Anthony Chang Daniel Brandt Denisse Yanez Lauren Talasnik Gianluca Carlesso Ronald Herbst Tammy O Utset Christine Labno Yahui Peng Yulei Jiang Maryellen L Giger Marcus R Clark Science Translational Medicine 02 Apr 2014 230ra46 Visualizing and quantifying the spatial relationships between T and B cells identifies adaptive immune cell networks in human inflammation Editor s Summary Abstract Full Text PDF Editors Choice Micro RNA managing Endothelial Regeneration By Ebru Erbay Science Translational Medicine 02 Apr 2014 230ec57 Systemic targeting of miR 126 production might be useful in treating atherosclerosis Full Text An Emerging Lung Cancer Biomarker By David E Gerber Science Translational Medicine 02 Apr 2014 230ec58 Molecular profiling of an exceptional response to the multitargeted kinase inhibitor sorafenib may have identified a new druggable oncogene in lung cancer Full Text Dancing with the Scars Choreography of the Macrophage Two Step After Myocardial Infarction By Elvin Price Science Translational Medicine 02 Apr 2014 230ec59 A nuclear receptor coordinates monocytes and macrophage subsets and functions after myocardial infarction to maximize healing Full Text Unveiling Neutrophil T Cell Interactions in HIV Infection By Henrique Serezani Science Translational Medicine 02 Apr 2014 230ec60 Human HIV infection causes T cell hyporesponsiveness by enhancing PD L1 expression on neutrophils promoting its binding to T cell PD 1 Full Text Something to Smile About in Stroke By Nathan White Science Translational Medicine 02 Apr 2014 230ec61 Facial nerve stimulation reduces the impact of ischemic stroke in a large animal model Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit About The Cover ONLINE

    Original URL path: http://stm.sciencemag.org/content/6/230 (2016-02-10)
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  • Table of Contents — April 09, 2014, 6 (231) | Science Translational Medicine
    Misako Hwang Ronald J Beyers Stanley G Leroy Stacy Maitland Thomas S Denney Nancy R Cox Henry J Baker Miguel Sena Esteves Douglas R Martin Science Translational Medicine 09 Apr 2014 231ra48 In a feline model of lysosomal storage disease intracranial gene therapy achieved therapeutic efficacy in the CNS and increased long term survival Editor s Summary Abstract Full Text PDF Immunological Visibility Posttranscriptional Regulation of Human NKG2D Ligands by the EGF Receptor Pathway By Pierre Vantourout Carrie Willcox Andrea Turner Chad M Swanson Yasmin Haque Olga Sobolev Anita Grigoriadis Andrew Tutt Adrian Hayday Science Translational Medicine 09 Apr 2014 231ra49 Environmental changes induce human NKG2D ligand expression immunological visibility through the EGFR stress response Editor s Summary Abstract Full Text PDF Editors Choice The GRM Face of Chondromyxoid Fibroma By Bishoy M Faltas Science Translational Medicine 09 Apr 2014 231ec62 Whole genome sequencing of chondromyxoid fibromas identified up regulation of a glutamate receptor encoding gene as a specific driver of tumorigenesis Full Text The Chicken or the Egg Checkpoint Markers Identify Tumor Specific T Cells in Melanoma By Marcela V Maus Science Translational Medicine 09 Apr 2014 231ec63 Surface expression of inhibitory receptors such as PD 1 identifies the tumor antigen specific CD8 T cells that infiltrate melanoma Full Text A Marker for Concussion By Daniel K Nishijima Science Translational Medicine 09 Apr 2014 231ec64 Total tau protein concentrations in blood correlate with clinical symptoms of concussion in ice hockey players Full Text How Can I Recover if You Won t Let Me Sleep By Eric C Stecker Science Translational Medicine 09 Apr 2014 231ec65 In a mouse model of myocardial infarction a 5 day period of diurnal disruption led to impaired cardiac healing after myocardial infarction Full Text More From Science Translational Medicine Current Table of Contents Archive

    Original URL path: http://stm.sciencemag.org/content/6/231 (2016-02-10)
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  • Table of Contents — April 16, 2014, 6 (232) | Science Translational Medicine
    Madhav V Dhodapkar Mario Sznol Biwei Zhao Ding Wang Richard D Carvajal Mary L Keohan Ellen Chuang Rachel E Sanborn Jose Lutzky John Powderly Harriet Kluger Sheela Tejwani Jennifer Green Venky Ramakrishna Andrea Crocker Laura Vitale Michael Yellin Thomas Davis Tibor Keler Science Translational Medicine 16 Apr 2014 232ra51 Dendritic cell targeting safely leads to integrated humoral and cellular immunity when combined with TLR agonists in cancer patients Editor s Summary Abstract Full Text PDF An Orally Available Small Molecule Polymerase Inhibitor Shows Efficacy Against a Lethal Morbillivirus Infection in a Large Animal Model By Stefanie A Krumm Dan Yan Elise S Hovingh Taylor J Evers Theresa Enkirch G Prabhakar Reddy Aiming Sun Manohar T Saindane Richard F Arrendale George Painter Dennis C Liotta Michael G Natchus Veronika von Messling Richard K Plemper Science Translational Medicine 16 Apr 2014 232ra52 An orally available shelf stable pan morbillivirus inhibitor targeting a viral polymerase effectively treats ferrets infected with a lethal dose of a measles like virus Editor s Summary Abstract Full Text PDF Editors Choice Antigenomic RNA as a Therapeutic Tool for Mitochondrial Diseases By Anshu Bhardwaj Science Translational Medicine 16 Apr 2014 232ec66 Targeting point mutations in mtDNA with antigenomic RNA restores normal mitochondrial function Full Text Inflammatory Web Catches Vessels By Vipul Chitalia Science Translational Medicine 16 Apr 2014 232ec67 A newly discovered candidate gene for a devastating pediatric vascular disease encodes an aberrant form of adenosine deaminase 2 which creates an inflammatory environment Full Text Matrix in the Driver s Seat By Charles S Dela Cruz Science Translational Medicine 16 Apr 2014 232ec68 The extracellular matrix can alter fibroblasts and affect the fibrogenic process that leads to disease Full Text Stopping Seizures After Brain Injury By Erik Musiek Science Translational Medicine 16 Apr 2014 232ec69 The FDA approved

    Original URL path: http://stm.sciencemag.org/content/6/232 (2016-02-10)
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  • Table of Contents — April 23, 2014, 6 (233) | Science Translational Medicine
    2014 233ra54 Neurotrophin gene delivery achieved by close field electroporation of mesenchymal cells adjacent to the cochlear implant improved hearing in deafened guinea pigs Editor s Summary Abstract Full Text PDF Reports Aspirin and the Risk of Colorectal Cancer in Relation to the Expression of 15 Hydroxyprostaglandin Dehydrogenase HPGD By Stephen P Fink Mai Yamauchi Reiko Nishihara Seungyoun Jung Aya Kuchiba Kana Wu Eunyoung Cho Edward Giovannucci Charles S Fuchs Shuji Ogino Sanford D Markowitz Andrew T Chan Science Translational Medicine 23 Apr 2014 233re2 Aspirin use is associated with a lower risk of colorectal cancer arising in association with high expression of 15 PGDH HPGD in normal colon mucosa Editor s Summary Abstract Full Text PDF Editors Choice A Pregnant Pause in Pancreatic Function By Saptarsi M Haldar Science Translational Medicine 23 Apr 2014 233ec70 The furan fatty acid metabolite CMPF might drive pathogenesis of gestational and type 2 diabetes in humans Full Text A Chink in Glioblastoma s Armor By Justin D Lathia Science Translational Medicine 23 Apr 2014 233ec71 Inducing vacuole formation with a quinolone alcohol based drug stimulates cell death in glioblastoma cells Full Text SNFing for Clues to the Genetics of Autism By Heather C Mefford Science Translational Medicine 23 Apr 2014 233ec72 Mutations in the ADNP gene which encodes a component of a nucleosome remodeling complex play a role in some cases of autism spectrum disorder Full Text Putting the Brakes on Inflammation to Control Sepsis By June L Round Science Translational Medicine 23 Apr 2014 233ec73 During sepsis VEGF C is induced by blood borne bacterial products and binds to its receptor down regulating inflammation Full Text Erratum Erratum for the Research Article Safety and Efficacy of an Injectable Extracellular Matrix Hydrogel for Treating Myocardial Infarction by S B Seif Naraghi J M

    Original URL path: http://stm.sciencemag.org/content/6/233 (2016-02-10)
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  • Table of Contents — April 30, 2014, 6 (234) | Science Translational Medicine
    s Summary Abstract Full Text PDF Modular Multiantigen T Cell Epitope Enriched DNA Vaccine Against Human Leishmaniasis By Shantanabha Das Anja Freier Thouraya Boussoffara Sushmita Das Detlef Oswald Florian O Losch Melanie Selka Nina Sacerdoti Sierra Gabriele Schönian Karl Heinz Wiesmüller Karin Seifert Matthias Schroff Christiane Juhls Charles L Jaffe Syamal Roy Pradeep Das Hechmi Louzir Simon L Croft Farrokh Modabber Peter Walden Science Translational Medicine 30 Apr 2014 234ra56 A DNA vaccine for the induction of cell mediated immunity against different types of leishmaniasis was developed and successfully tested in human cell culture systems for immunogenicity and an animal model for prophylaxis Editor s Summary Abstract Full Text PDF Disease Risk Factors Identified Through Shared Genetic Architecture and Electronic Medical Records By Li Li David J Ruau Chirag J Patel Susan C Weber Rong Chen Nicholas P Tatonetti Joel T Dudley Atul J Butte Science Translational Medicine 30 Apr 2014 234ra57 Twenty six traits were associated with diseases through similarities in genetic variation and validated from electronic medical records Editor s Summary Abstract Full Text PDF An Acellular Biologic Scaffold Promotes Skeletal Muscle Formation in Mice and Humans with Volumetric Muscle Loss By Brian M Sicari J Peter Rubin Christopher L Dearth Matthew T Wolf Fabrisia Ambrosio Michael Boninger Neill J Turner Douglas J Weber Tyler W Simpson Aaron Wyse Elke H P Brown Jenna L Dziki Lee E Fisher Spencer Brown Stephen F Badylak Science Translational Medicine 30 Apr 2014 234ra58 Scaffolds composed of cell free extracellular matrix promote de novo formation of functional skeletal muscle tissue in sites of volumetric muscle loss Editor s Summary Abstract Full Text PDF Potent Neutralization of MERS CoV by Human Neutralizing Monoclonal Antibodies to the Viral Spike Glycoprotein By Liwei Jiang Nianshuang Wang Teng Zuo Xuanling Shi Kwok Man Vincent Poon Yongkang Wu Fei Gao Danyang Li Ruoke Wang Jianying Guo Lili Fu Kwok Yung Yuen Bo Jian Zheng Xinquan Wang Linqi Zhang Science Translational Medicine 30 Apr 2014 234ra59 Human neutralizing monoclonal antibody could serve as a therapeutic intervention against MERS CoV infection Editor s Summary Abstract Full Text PDF Editors Choice SYMPLICITY Not as Simple as One Two Three By Kumaran Kolandaivelu Science Translational Medicine 30 Apr 2014 234ec74 Extensive pre and early clinical evidence indicated that renal sympathetic denervation effectively treats hypertension yet the well controlled SYMPLICITY HTN 3 trial failed Full Text PGE2 The Immune System Tamer By Mathieu Lemaire Science Translational Medicine 30 Apr 2014 234ec75 By chelating bioactive PGE2 a molecule with immunosuppressive properties albumin helps preserve normal immune function Full Text An Exciting Way to Heal By Anne Schaefer Science Translational Medicine 30 Apr 2014 234ec76 Enhancing depression causing hyperexcitability in dopamine neurons alleviates depression like behavior in mice Full Text Carbon Nanotubes Are Picky Hitchhikers By Matthias Stephan Science Translational Medicine 30 Apr 2014 234ec77 A new class of nanoparticles are taken up by a subset of monocytes in vivo for imaging and therapy of cancer cardiovascular disease and certain autoimmune diseases Full

    Original URL path: http://stm.sciencemag.org/content/6/234 (2016-02-10)
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  • Table of Contents — May 07, 2014, 6 (235) | Science Translational Medicine
    s Summary Abstract Full Text PDF CpG ODN Nanorings Induce IFNα from Plasmacytoid Dendritic Cells and Demonstrate Potent Vaccine Adjuvant Activity By Bilgi Gungor Fuat Cem Yagci Gizem Tincer Banu Bayyurt Esin Alpdundar Soner Yildiz Mine Ozcan Ihsan Gursel Mayda Gursel Science Translational Medicine 07 May 2014 235ra61 Nanorings act as CpG oligodeoxynucleotide surrogates that may function as vaccine adjuvants and anticancer and antiviral agents Editor s Summary Abstract Full Text PDF Reports Expression of the Iron Hormone Hepcidin Distinguishes Different Types of Anemia in African Children By Sant Rayn Pasricha Sarah H Atkinson Andrew E Armitage Shivani Khandwala Jacobien Veenemans Sharon E Cox Lucy A Eddowes Theodore Hayes Conor P Doherty Ayse Y Demir Edwin Tijhaar Hans Verhoef Andrew M Prentice Hal Drakesmith Science Translational Medicine 07 May 2014 235re3 The iron hormone hepcidin correctly identifies African children in whom iron supplementation is most likely to be beneficial Editor s Summary Abstract Full Text PDF Editors Choice Obesity Paves the Highway for Colon Cancer By Simon W Beaven Science Translational Medicine 07 May 2014 235ec79 Obesity resets enhancers of gene expression in the colon epithelium affecting signaling pathways that initiate and promote colon cancer Full Text Magnetic Resonance It s a Gas By Chester L Drum Science Translational Medicine 07 May 2014 235ec80 A genetically encoded magnetic resonance imaging MRI reporter uses bacterial proteins to encapsulate nanosized bubbles of xenon gas Full Text How to Build a Better Bone Tumor By Kara L Spiller Science Translational Medicine 07 May 2014 235ec81 Cancer cells behave more like native tumors when they are cultured in a tissue engineered construct designed to recapitulate important aspects of the tumor microenvironment Full Text Somatic Cell Nuclear Transfer Is All Grown Up By Paul J Tesar Science Translational Medicine 07 May 2014 235ec82 Adult human

    Original URL path: http://stm.sciencemag.org/content/6/235 (2016-02-10)
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