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  • Table of Contents — May 14, 2014, 6 (236) | Science Translational Medicine
    Devin Sok Katie J Doores Bryan Briney Khoa M Le Karen L Saye Francisco Alejandra Ramos Daniel W Kulp Jean Philippe Julien Sergey Menis Lalinda Wickramasinghe Michael S Seaman William R Schief Ian A Wilson Pascal Poignard Dennis R Burton Science Translational Medicine 14 May 2014 236ra63 HIV broadly neutralizing monoclonal antibodies targeting the high mannose patch of Env can use alternate glycan sites for neutralization Editor s Summary Abstract Full Text PDF PHD Inhibition Mitigates and Protects Against Radiation Induced Gastrointestinal Toxicity via HIF2 By Cullen M Taniguchi Yu Rebecca Miao Anh N Diep Colleen Wu Erinn B Rankin Todd F Atwood Lei Xing Amato J Giaccia Science Translational Medicine 14 May 2014 236ra64 Pharmacologic inhibition or knockout of HIF prolyl hydroxylases in mice reduces morbidity and mortality from radiation induced gastrointestinal syndrome Editor s Summary Abstract Full Text PDF Reports An Antidepressant Decreases CSF Aβ Production in Healthy Individuals and in Transgenic AD Mice By Yvette I Sheline Tim West Kevin Yarasheski Robert Swarm Mateusz S Jasielec Jonathan R Fisher Whitney D Ficker Ping Yan Chengjie Xiong Christine Frederiksen Monica V Grzelak Robert Chott Randall J Bateman John C Morris Mark A Mintun Jin Moo Lee John R Cirrito Science Translational Medicine 14 May 2014 236re4 The antidepressant drug citalopram decreased CSF amyloid β in healthy humans and in an aged transgenic mouse model of Alzheimer s disease it decreased ISF amyloid β in a dose dependent manner Editor s Summary Abstract Full Text PDF Editors Choice Bacteria Driven Atherosclerosis By Ebru Erbay Science Translational Medicine 14 May 2014 236ec83 Asymptomatic Helicobacter cinaedi infection induces macrophage proinflammatory responses and promotes atherosclerosis Full Text Finding Needles in the Haystack By David E Gerber Science Translational Medicine 14 May 2014 236ec84 A noninvasive urinary metabolic profile may identify early lung cancer and predict outcomes Full Text The Liver Speaks Up in the Sugar Debate By Elvin Price Science Translational Medicine 14 May 2014 236ec85 Even the moderate amount of fructose in a 12 oz can of soda impairs lipid metabolism in the liver of healthy volunteers Full Text Pentraxin 3 Sends Urinary Tract Infection Down the Drain By Henrique Serezani Science Translational Medicine 14 May 2014 236ec86 The pattern recognition receptor pentraxin 3 is essential to control uropathogenic Escherichia coli infection in the urinary tract Full Text Machine Learning to the Rescue By Nathan J White Science Translational Medicine 14 May 2014 236ec87 A new approach using vital sign complexity analysis and machine learning improves prediction of the need for lifesaving maneuvers in trauma patients Full Text Podcast Science Translational Medicine Podcast 14 May 2014 By Yvette I Sheline Orla Smith Science Translational Medicine 14 May 2014 236pc1 Yvette Sheline discusses an antidepressant drug that decreases amyloid β in the cerebrospinal fluid of healthy people Abstract Erratum Erratum for the Research Article A Common Mutation in the Defensin DEFB126 Causes Impaired Sperm Function and Subfertility by T L Tollner S A Venners E J Hollox A I Yudin X Liu

    Original URL path: http://stm.sciencemag.org/content/6/236 (2016-02-10)
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  • Table of Contents — May 21, 2014, 6 (237) | Science Translational Medicine
    Patuto Christine Bernsmeier Francesca Ronchi Madeleine Wyss Deborah Stroka Nina Dickgreber Markus H Heim Kathy D McCoy Andrew J Macpherson Science Translational Medicine 21 May 2014 237ra66 The liver forms a firewall that protects against vascular borne gut microbes and is commonly impaired in liver disease Editor s Summary Abstract Full Text PDF Disruption of CXCR2 Mediated MDSC Tumor Trafficking Enhances Anti PD1 Efficacy By Steven L Highfill Yongzhi Cui Amber J Giles Jillian P Smith Hua Zhang Elizabeth Morse Rosandra N Kaplan Crystal L Mackall Science Translational Medicine 21 May 2014 237ra67 Preventing trafficking of myeloid derived suppressor cells to the tumor site enhances the efficiency of checkpoint blockade Editor s Summary Abstract Full Text PDF Merlin Deficiency Predicts FAK Inhibitor Sensitivity A Synthetic Lethal Relationship By Irina M Shapiro Vihren N Kolev Christian M Vidal Yuwaraj Kadariya Jennifer E Ring Quentin Wright David T Weaver Craig Menges Mahesh Padval Andrea I McClatchey Qunli Xu Joseph R Testa Jonathan A Pachter Science Translational Medicine 21 May 2014 237ra68 FAK inhibitor treatment is effective against Merlin negative mesothelioma tumors and preferentially targets cancer stem cells Editor s Summary Abstract Full Text PDF Editors Choice SNFing Out Vulnerability in Cancer By Bishoy M Faltas Science Translational Medicine 21 May 2014 237ec88 SWI SWF proteins including ARID1A and ARID1B are required for cellular resistance to DNA damage Full Text The Long Awaited Marriage of Cancer Genomics and Immunotherapy Bears Fruit By Marcela V Maus Science Translational Medicine 21 May 2014 237ec89 A cholangiocarcinoma patient responded to adoptive T cell therapy specific to a mutation identified by whole exome sequencing Full Text Losing Brain By Daniel K Nishijima Science Translational Medicine 21 May 2014 237ec90 A study of college football players shows that more years of active play are associated with smaller volumes

    Original URL path: http://stm.sciencemag.org/content/6/237 (2016-02-10)
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  • Table of Contents — May 28, 2014, 6 (238) | Science Translational Medicine
    2014 238ra70 CTLA 4 blockade induces T cell repertoire turnover but high frequency clonotypes are maintained in patients with favorable outcomes Editor s Summary Abstract Full Text PDF Hematopoietic Stem Cell Origin of BRAF V600E Mutations in Hairy Cell Leukemia By Stephen S Chung Eunhee Kim Jae H Park Young Rock Chung Piro Lito Julie Teruya Feldstein Wenhuo Hu Wendy Beguelin Sebastien Monette Cihangir Duy Raajit Rampal Leon Telis Minal Patel Min Kyung Kim Kety Huberman Nancy Bouvier Michael F Berger Ari M Melnick Neal Rosen Martin S Tallman Christopher Y Park Omar Abdel Wahab Science Translational Medicine 28 May 2014 238ra71 The cell of origin for the chronic lymphoproliferative disorder hairy cell leukemia is a long term hematopoietic stem cell as shown through human genetic data and murine genetic models Editor s Summary Abstract Full Text PDF CD4 T Cells with Effector Memory Phenotype and Function Develop in the Sterile Environment of the Fetus By Xiaoming Zhang Brian Mozeleski Sebastien Lemoine Edith Dériaud Annick Lim Dania Zhivaki Elie Azria Camille Le Ray Gwenaelle Roguet Odile Launay Anne Vanet Claude Leclerc Richard Lo Man Science Translational Medicine 28 May 2014 238ra72 Umbilical cord blood from healthy neonates with no known infectious exposure contains T cells with an effector memory like phenotype Editor s Summary Abstract Full Text PDF Editors Choice Reactive Species Contribute to Antibiotic Mediated Killing By Anshu Bhardwaj Science Translational Medicine 28 May 2014 238ec92 Damaging reactive oxygen species drives antibiotic mediated killing Full Text Angiotensin Blockade A Double Edged Sword in Renal Failure By Vipul Chitalia Science Translational Medicine 28 May 2014 238ec93 Angiotensin receptor suppression in macrophages infiltrating damaged kidneys exacerbates renal fibrosis Full Text A Maternal Microbial Gift for the Baby By Charles S Dela Cruz Science Translational Medicine 28 May 2014 238ec94 Alteration of

    Original URL path: http://stm.sciencemag.org/content/6/238 (2016-02-10)
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  • Table of Contents — June 04, 2014, 6 (239) | Science Translational Medicine
    Common Therapeutic Targets in Cardiometabolic Disease By Gabrielle Fredman Lale Ozcan Ira Tabas Science Translational Medicine 04 Jun 2014 239ps5 Cardiovascular disease and insulin resistance syndrome interactions provide joint therapeutic targets Abstract Full Text PDF Human Stem Cells for Modeling Heart Disease and for Drug Discovery By Elena Matsa Paul W Burridge Joseph C Wu Science Translational Medicine 04 Jun 2014 239ps6 This Perspective highlights recent research progress in the use of stem cells and progenitor cells for disease modeling drug discovery and cardiac regeneration Abstract Full Text PDF State of the Art Review Imaging and Nanomedicine in Inflammatory Atherosclerosis By Willem J M Mulder Farouc A Jaffer Zahi A Fayad Matthias Nahrendorf Science Translational Medicine 04 Jun 2014 239sr1 The integration of immunology and cardiovascular medicine with engineering and nanotechnology will yield precision diagnostics and efficient therapeutics for atherosclerosis and its ischemic complications Abstract Full Text PDF Review Strategies for Cardiac Regeneration and Repair By Zhiqiang Lin William T Pu Science Translational Medicine 04 Jun 2014 239rv1 Regenerative medicine strategies that enhance heart repair are being pursued to face the growing heart disease epidemic Abstract Full Text PDF Editors Choice Metabolic Syndrome A Family Affair By Saptarsi M Haldar Science Translational Medicine 04 Jun 2014 239ec96 A rare genetic mutation found to cause human metabolic syndrome may shed light on more common forms of cardiometabolic disease Full Text Vaping Vaccine or Virus By Kumaran Kolandaivelu Science Translational Medicine 04 Jun 2014 239ec97 Despite the growing popularity of electronic cigarettes little is known about whether these nicotine delivery devices hinder or help smokers in their efforts to quit Full Text Removing the Veil from Cancer Stem Cells By Justin D Lathia Science Translational Medicine 04 Jun 2014 239ec98 The evaluation of human patient specimens provides in vivo evidence that cancer

    Original URL path: http://stm.sciencemag.org/content/6/239 (2016-02-10)
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  • Table of Contents — June 11, 2014, 6 (240) | Science Translational Medicine
    Macrophages differentiated from monocytes or induced pluripotent stem cells derived from patients with Gaucher disease facilitate investigation of disease pathogenesis and validation of new candidate drugs Editor s Summary Abstract Full Text PDF Identification of a New Modulator of the Intercalated Disc in a Zebrafish Model of Arrhythmogenic Cardiomyopathy By Angeliki Asimaki Sudhir Kapoor Eva Plovie Anne Karin Arndt Edward Adams ZhenZhen Liu Cynthia A James Daniel P Judge Hugh Calkins Jared Churko Joseph C Wu Calum A MacRae André G Kléber Jeffrey E Saffitz Science Translational Medicine 11 Jun 2014 240ra74 Drug screening in a zebrafish model of arrhythmogenic cardiomyopathy identified a small molecule that remodels the intercalated disc Editor s Summary Abstract Full Text PDF Alkylphosphocholine Analogs for Broad Spectrum Cancer Imaging and Therapy By Jamey P Weichert Paul A Clark Irawati K Kandela Abram M Vaccaro William Clarke Marc A Longino Anatoly N Pinchuk Mohammed Farhoud Kyle I Swanson John M Floberg Joseph Grudzinski Benjamin Titz Anne M Traynor Hong En Chen Lance T Hall Christopher J Pazoles Perry J Pickhardt John S Kuo Science Translational Medicine 11 Jun 2014 240ra75 Tumor specific alkylphosphocholine analogs were evaluated as imaging and therapy agents in patients and in animal models of human cancer Editor s Summary Abstract Full Text PDF Chitinase 3 Like 1 Suppresses Injury and Promotes Fibroproliferative Responses in Mammalian Lung Fibrosis By Yang Zhou Hong Peng Huanxing Sun Xueyan Peng Chuyan Tang Ye Gan Xiaosong Chen Aditi Mathur Buqu Hu Martin D Slade Ruth R Montgomery Albert C Shaw Robert J Homer Eric S White Chang Min Lee Meagan W Moore Mridu Gulati Chun Geun Lee Jack A Elias Erica L Herzog Science Translational Medicine 11 Jun 2014 240ra76 Chitinase 3 like 1 protects against lung injury but has a profibrotic role during the repair phase Editor s Summary Abstract Full Text PDF Editors Choice WANTED Natural Born Sickler By Mathieu Lemaire Science Translational Medicine 11 Jun 2014 240ec101 Sixty five years after Pauling discovered the molecular basis of sickle cell anemia the lipid S1P is found to be a critical player Full Text Straight Shooters Peptibodies Take Aim By Matthias Stephan Science Translational Medicine 11 Jun 2014 240ec102 Peptide antibodies peptibodies aim for and selectively deplete myeloid immune suppressor cells leading to retarded tumor growth in mice Full Text Antimicrobial Drug Resistance in All Four Corners of the Earth By Ephraim L Tsalik Science Translational Medicine 11 Jun 2014 240ec103 Antibiotic resistance genes exist in multiple environmental and biological sources worldwide Full Text Podcast Science Translational Medicine Podcast 11 June 2014 By John S Kuo Megan Frisk Science Translational Medicine 11 Jun 2014 240pc2 John S Kuo describes a new class of small molecule cancer selective imaging and therapeutic agents Abstract More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit About The Cover ONLINE COVER A Broad

    Original URL path: http://stm.sciencemag.org/content/6/240 (2016-02-10)
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  • Table of Contents — June 18, 2014, 6 (241) | Science Translational Medicine
    established autoimmune diseases Editor s Summary Abstract Full Text PDF Selective Targeting of TGF β Activation to Treat Fibroinflammatory Airway Disease By Shunsuke Minagawa Jianlong Lou Robert I Seed Anthony Cormier Shenping Wu Yifan Cheng Lynne Murray Ping Tsui Jane Connor Ronald Herbst Cedric Govaerts Tyren Barker Stephanie Cambier Haruhiko Yanagisawa Amanda Goodsell Mitsuo Hashimoto Oliver J Brand Ran Cheng Royce Ma Kate J McKnelly Weihua Wen Arthur Hill David Jablons Paul Wolters Hideya Kitamura Jun Araya Andrea J Barczak David J Erle Louis F Reichardt James D Marks Jody L Baron Stephen L Nishimura Science Translational Medicine 18 Jun 2014 241ra79 Therapeutic targeting of an extended closed conformation of the integrin αvβ8 inhibits TGF β activation and ameliorates symptoms of experimental airway disease in mice Editor s Summary Abstract Full Text PDF IL 17 and GM CSF Expression Are Antagonistically Regulated by Human T Helper Cells By Rebecca Noster René Riedel Mir Farzin Mashreghi Helena Radbruch Lutz Harms Claudia Haftmann Hyun Dong Chang Andreas Radbruch Christina E Zielinski Science Translational Medicine 18 Jun 2014 241ra80 GM CSF producing T helper cells in humans follow a distinct regulation program as compared to T H 17 cells and are associated with multiple sclerosis Editor s Summary Abstract Full Text PDF Editors Choice Taking Cancer Cells Out of Circulation By Chester L Drum Science Translational Medicine 18 Jun 2014 241ec104 Circulating cancer cells produce patient specific tumors in mice that predict response to chemotherapy Full Text A Stroke of Genius By Kara L Spiller Science Translational Medicine 18 Jun 2014 241ec105 Amyloid β targeted nanoparticles allow early detection and treatment of stroke inducing cerebrovascular inflammation Full Text A Punch to the Gut IL 9 Promotes Ulcerative Colitis By Jie Sun Science Translational Medicine 18 Jun 2014 241ec106 Interleukin 9 amplifies mucosal inflammation

    Original URL path: http://stm.sciencemag.org/content/6/241 (2016-02-10)
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  • Table of Contents — June 25, 2014, 6 (242) | Science Translational Medicine
    242ra81 Persistent HCV infection does not preclude the establishment of liver allograft tolerance in humans Editor s Summary Abstract Full Text PDF Therapeutic Treatment of Nipah Virus Infection in Nonhuman Primates with a Neutralizing Human Monoclonal Antibody By Thomas W Geisbert Chad E Mire Joan B Geisbert Yee Peng Chan Krystle N Agans Friederike Feldmann Karla A Fenton Zhongyu Zhu Dimiter S Dimitrov Dana P Scott Katharine N Bossart Heinz Feldmann Christopher C Broder Science Translational Medicine 25 Jun 2014 242ra82 A monoclonal antibody against Nipah virus has in vivo efficacy in a nonhuman primate Editor s Summary Abstract Full Text PDF Activity of Broad Spectrum T Cells as Treatment for AdV EBV CMV BKV and HHV6 Infections after HSCT By Anastasia Papadopoulou Ulrike Gerdemann Usha L Katari Ifigenia Tzannou Hao Liu Caridad Martinez Kathryn Leung George Carrum Adrian P Gee Juan F Vera Robert A Krance Malcolm K Brenner Cliona M Rooney Helen E Heslop Ann M Leen Science Translational Medicine 25 Jun 2014 242ra83 Rapidly generated broad spectrum T cells can simultaneously treat multiple viral infections after hematopoietic stem cell transplant Editor s Summary Abstract Full Text PDF COX 2 Inhibition Potentiates Antiangiogenic Cancer Therapy and Prevents Metastasis in Preclinical Models By Lihong Xu Janine Stevens Mary Beth Hilton Steven Seaman Thomas P Conrads Timothy D Veenstra Daniel Logsdon Holly Morris Deborah A Swing Nimit L Patel Joseph Kalen Diana C Haines Enrique Zudaire Brad St Croix Science Translational Medicine 25 Jun 2014 242ra84 Inhibition of cyclooxygenase 2 COX 2 inhibits angiogenesis suppresses tumor growth and augments the effects of traditional angiogenesis inhibitors Editor s Summary Abstract Full Text PDF Editors Choice Turbulent Times for the Atherosclerosis Epigenome By Ebru Erbay Science Translational Medicine 25 Jun 2014 242ec108 Therapeutics targeting DNA methylation may reverse atherosclerosis Full Text Treatment Guidance from the Blood By David E Gerber Science Translational Medicine 25 Jun 2014 242ec109 Circulating tumor cells from small cell lung cancer yield genomic information and animal models Full Text Boys Versus Girls T Lymphocytes in Hypertension By Elvin Price Science Translational Medicine 25 Jun 2014 242ec110 Immune cells contribute to the development of hypertension in males but not females Full Text CD147 Hooks Meningococcus By Henrique Serezani Science Translational Medicine 25 Jun 2014 242ec111 CD147 is a critical host receptor for the meningococcal pilus components PilE and PilV in human endothelial cells Full Text A New Biological Nano Superglue By Nathan J White Science Translational Medicine 25 Jun 2014 242ec112 A fast easily applied nano superglue can close both deep and superficial wounds and can attach materials to biological tissues Full Text Letter Comment on CD4 T Cell Autoimmunity to Hypocretin Orexin and Cross Reactivity to a 2009 H1N1 Influenza A Epitope in Narcolepsy By Robbert van der Most Martine Wettendorff Bruce Innis Emmanuel Hanon Science Translational Medicine 25 Jun 2014 242le3 Scientists from the maker of the Pandemrix vaccine for influenza present their views on results linking epitopes in influenza and narcolepsy Abstract Full Text PDF More

    Original URL path: http://stm.sciencemag.org/content/6/242 (2016-02-10)
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  • Table of Contents — July 02, 2014, 6 (243) | Science Translational Medicine
    Byrne Science Translational Medicine 02 Jul 2014 243ra85 A humanized monoclonal antibody that targets the membrane IgE B cell receptor was associated with improvements in asthmatic airway responses Editor s Summary Abstract Full Text PDF TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis By Gernot Kleinberger Yoshinori Yamanishi Marc Suárez Calvet Eva Czirr Ebba Lohmann Elise Cuyvers Hanne Struyfs Nadine Pettkus Andrea Wenninger Weinzierl Fargol Mazaheri Sabina Tahirovic Alberto Lleó Daniel Alcolea Juan Fortea Michael Willem Sven Lammich José L Molinuevo Raquel Sánchez Valle Anna Antonell Alfredo Ramirez Michael T Heneka Kristel Sleegers Julie van der Zee Jean Jacques Martin Sebastiaan Engelborghs Asli Demirtas Tatlidede Henrik Zetterberg Christine Van Broeckhoven Hakan Gurvit Tony Wyss Coray John Hardy Marco Colonna Christian Haass Science Translational Medicine 02 Jul 2014 243ra86 Loss of TREM2 function impairs phagocytosis and correlates with decreased soluble TREM2 in biological fluids of patients with neurodegenerative disorders Editor s Summary Abstract Full Text PDF Recipient NK cell inactivation and intestinal barrier loss are required for MHC matched graft versus host disease By Sam C Nalle H Aimee Kwak Karen L Edelblum Nora E Joseph Gurminder Singh Galina F Khramtsova Eric D Mortenson Peter A Savage Jerrold R Turner Science Translational Medicine 02 Jul 2014 243ra87 Pretransplant conditioning promotes minor mismatch GVHD by causing intestinal barrier loss and depleting NK cells Editor s Summary Abstract Full Text PDF Neutralizing antibodies to HIV 1 envelope protect more effectively in vivo than those to the CD4 receptor By Amarendra Pegu Zhi yong Yang Jeffrey C Boyington Lan Wu Sung Youl Ko Stephen D Schmidt Krisha McKee Wing Pui Kong Wei Shi Xuejun Chen John Paul Todd Norman L Letvin Jinghe Huang Martha C Nason James A Hoxie Peter D Kwong Mark Connors Srinivas S Rao John R Mascola Gary J Nabel Science Translational Medicine 02 Jul 2014 243ra88 Neutralizing antibodies to HIV 1 envelope protect more effectively than an antibody to the CD4 cell receptor in rhesus macaques Editor s Summary Abstract Full Text PDF Editors Choice A CRISPR Way to Move Things Around By Bishoy M Faltas Science Translational Medicine 02 Jul 2014 243ec113 The CRISPR Cas9 system can be used to replicate oncogenic chromosomal translocations Full Text C ing Bacterial Infections By Daniel K Nishijima Science Translational Medicine 02 Jul 2014 243ec114 The diagnostic accuracy of the C reactive protein test for identifying bacterial infections in febrile children was improved by including the time of fever onset Full Text A Nonshocking New Way to Prevent Sudden Death By Eric C Stecker Science Translational Medicine 02 Jul 2014 243ec115 Cardiac gene transfer in a mouse model of ventricular tachycardia eliminated life threatening arrhythmias Full Text Podcast Science Translational Medicine Podcast 2 July 2014 By Jeffrey M Harris Lawren C Wu Annalisa VanHook Science Translational Medicine 02 Jul 2014 243pc3 Jeffrey M Harris and Lawren C Wu describe how the drug quilizumab reduced allergen induced asthmatic airway responses in mild asthmatics Abstract More From Science Translational Medicine Current Table

    Original URL path: http://stm.sciencemag.org/content/6/243 (2016-02-10)
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