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  • Table of Contents — September 03, 2014, 6 (252) | Science Translational Medicine
    mechanism of BCR ABL independent imatinib resistance in chronic myeloid leukemia By Leyuan Ma Yi Shan Robert Bai Liting Xue Christopher A Eide Jianhong Ou Lihua J Zhu Lloyd Hutchinson Jan Cerny Hanna Jean Khoury Zhi Sheng Brian J Druker Shaoguang Li Michael R Green Science Translational Medicine 03 Sep 2014 252ra121 A large scale RNA interference screen reveals a new mechanism of imatinib resistance in chronic myeloid leukemia that can be therapeutically targeted Editor s Summary Abstract Full Text PDF Prostate cancer cell stromal cell crosstalk via FGFR1 mediates antitumor activity of dovitinib in bone metastases By Xinhai Wan Paul G Corn Jun Yang Nallasivam Palanisamy Michael W Starbuck Eleni Efstathiou Elsa M Li Ning Tapia Amado J Zurita Ana Aparicio Murali K Ravoori Elba S Vazquez Dan R Robinson Yi Mi Wu Xuhong Cao Matthew K Iyer Wallace McKeehan Vikas Kundra Fen Wang Patricia Troncoso Arul M Chinnaiyan Christopher J Logothetis Nora M Navone Science Translational Medicine 03 Sep 2014 252ra122 Dovitinib is therapeutically active in a subset of patients with prostate cancer bone metastases partly due to blockade of FGFR mediated stromal epithelial interactions in the bone microenvironment Editor s Summary Abstract Full Text PDF Effective diagnosis of genetic disease by computational phenotype analysis of the disease associated genome By Tomasz Zemojtel Sebastian Köhler Luisa Mackenroth Marten Jäger Jochen Hecht Peter Krawitz Luitgard Graul Neumann Sandra Doelken Nadja Ehmke Malte Spielmann Nancy Christine Øien Michal R Schweiger Ulrike Krüger Götz Frommer Björn Fischer Uwe Kornak Ricarda Flöttmann Amin Ardeshirdavani Yves Moreau Suzanna E Lewis Melissa Haendel Damian Smedley Denise Horn Stefan Mundlos Peter N Robinson Science Translational Medicine 03 Sep 2014 252ra123 Patients with genetic disease of unknown causes can be rapidly diagnosed by bioinformatic analysis of disease associated DNA sequences and phenotype Editor s Summary Abstract Full Text PDF The HMGB1 RAGE axis mediates traumatic brain injury induced pulmonary dysfunction in lung transplantation By Daniel J Weber Adam S A Gracon Matthew S Ripsch Amanda J Fisher Bo M Cheon Pankita H Pandya Ragini Vittal Maegan L Capitano Youngsook Kim Yohance M Allette Amanda A Riley Brian P McCarthy Paul R Territo Gary D Hutchins Hal E Broxmeyer George E Sandusky Fletcher A White David S Wilkes Science Translational Medicine 03 Sep 2014 252ra124 Traumatic brain injury induces acute lung injury that negatively impacts the physiology of the donor lung before and after lung transplantation Editor s Summary Abstract Full Text PDF Editors Choice Human Cells Finally Open for Cancer Business By Mathieu Lemaire Science Translational Medicine 03 Sep 2014 252ec150 Insertional mutagenesis of normal human cells with a transposon expressing lentivirus leads to better cancer cell models Full Text Old Age Interfer on ing By Anne Schaefer Science Translational Medicine 03 Sep 2014 252ec151 Age dependent cognitive decline is linked to an increased interferon response in brain circulatory system interface Full Text Window of Opportunity By Matthias Stephan Science Translational Medicine 03 Sep 2014 252ec152 Carbon nanotubes along with new medical imaging tools provide a

    Original URL path: http://stm.sciencemag.org/content/6/252 (2016-02-10)
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  • Table of Contents — September 10, 2014, 6 (253) | Science Translational Medicine
    S Fauci Science Translational Medicine 10 Sep 2014 253ps10 Emerging viral diseases continue to threaten human health but recent scientific advances are better positioning us to treat them and to detect and control the causative pathogens Abstract Full Text PDF Contemporary Vaccine Challenges Improving Global Health One Shot at a Time By Walter A Orenstein Katherine Seib Duncan Graham Rowe Seth Berkley Science Translational Medicine 10 Sep 2014 253ps11 Developing new vaccines for additional diseases as well as improving their supply and delivery is crucial for global health Abstract Full Text PDF Review Point of care and point of procedure optical imaging technologies for primary care and global health By Stephen A Boppart Rebecca Richards Kortum Science Translational Medicine 10 Sep 2014 253rv2 Optical imaging technologies can improve frontline health care in low and high resource settings resulting in more rapid and accurate diagnoses and more immediate and appropriate therapies Abstract Full Text PDF Editors Choice The Ubiquitinase Pathway Takes Center Stage in Viral Myocarditis By Chester L Drum Science Translational Medicine 10 Sep 2014 253ec155 Targeted degradation of a viral protease by the cardiac myocyte ubiquitinase system keeps viral replication and cardiac damage at bay Full Text Culture Shock Brain Like Tissue Grown in Vitro Has Potential By Kara L Spiller Science Translational Medicine 10 Sep 2014 253ec156 Careful biomaterial design supports generation of electrophysiologically relevant brain like tissue in vitro Full Text Two Paths Diverged in a Schwann Cell By Paul J Tesar Science Translational Medicine 10 Sep 2014 253ec157 Balanced activation of both Mek Erk and PI3K Akt pathways in Schwann cells enhances myelination and enables functional recovery in a rodent model of Charcot Marie Tooth disease Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission

    Original URL path: http://stm.sciencemag.org/content/6/253 (2016-02-10)
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  • Table of Contents — September 17, 2014, 6 (254) | Science Translational Medicine
    Full Text PDF EbpA vaccine antibodies block binding of Enterococcus faecalis to fibrinogen to prevent catheter associated bladder infection in mice By Ana L Flores Mireles Jerome S Pinkner Michael G Caparon Scott J Hultgren Science Translational Medicine 17 Sep 2014 254ra127 Binding to host fibrinogen is a critical event in Enterococcus faecalis pathogenesis in catheter associated urinary tract infections in mice Editor s Summary Abstract Full Text PDF Anti CTLA 4 therapy broadens the melanoma reactive CD8 T cell response By Pia Kvistborg Daisy Philips Sander Kelderman Lois Hageman Christian Ottensmeier Deborah Joseph Pietras Marij J P Welters Sjoerd van der Burg Ellen Kapiteijn Olivier Michielin Emanuela Romano Carsten Linnemann Daniel Speiser Christian Blank John B Haanen Ton N Schumacher Science Translational Medicine 17 Sep 2014 254ra128 Anti CTLA 4 treatment increases the diversity of the melanoma specific CD8 T cell response Editor s Summary Abstract Full Text PDF Broadly neutralizing antibodies abrogate established hepatitis C virus infection By Ype P de Jong Marcus Dorner Michiel C Mommersteeg Jing W Xiao Alejandro B Balazs Justin B Robbins Benjamin Y Winer Sherif Gerges Kevin Vega Rachael N Labitt Bridget M Donovan Erick Giang Anuradha Krishnan Luis Chiriboga Michael R Charlton Dennis R Burton David Baltimore Mansun Law Charles M Rice Alexander Ploss Science Translational Medicine 17 Sep 2014 254ra129 HCV specific neutralizing antibodies protect humanized mice from challenge and suppress established infections Editor s Summary Abstract Full Text PDF Editors Choice Sumo Wrestling Atherosclerosis By Ebru Erbay Science Translational Medicine 17 Sep 2014 254ec158 Therapeutic targeting of nuclear receptor SUMOylation may alter the course of atherosclerosis Full Text A New Role for Epigenetic Therapy By David E Gerber Science Translational Medicine 17 Sep 2014 254ec159 Demethylating agents may alleviate cancer associated pain Full Text Vitamin D A Passenger Not a Driver in Cardiovascular Disease By Elvin Price Science Translational Medicine 17 Sep 2014 254ec160 Vitamin D deficiency results from abnormal lipid concentrations and is not a contributor to the development of atherosclerosis Full Text A Cytokine a Day Keeps Diabetes Away By Henrique Serezani Science Translational Medicine 17 Sep 2014 254ec161 The cytokine interleukin 37 inhibits chronic inflammation and improves insulin sensitivity in obese mice and humans Full Text Lights Microscope Action By Nathan J White Science Translational Medicine 17 Sep 2014 254ec162 Fine needle tissue biopsies take center stage with real time live confocal microscopy Full Text Letters Author response to comment on The placenta harbors a unique microbiome By Kjersti M Aagaard Science Translational Medicine 17 Sep 2014 254lr3 Placental samples contain very small volumes of blood and blood borne bacteria are not likely to be detected in microbiome analysis Full Text PDF Comment on The placenta harbors a unique microbiome By Harvey J Kliman Science Translational Medicine 17 Sep 2014 254le4 Microbiota found in the placenta may actually be bacteria or bacterial fragments in maternal blood Full Text PDF Errata Erratum for the Research Article Gene Therapy for Wiskott Aldrich Syndrome Long Term Efficacy and Genotoxicity by

    Original URL path: http://stm.sciencemag.org/content/6/254 (2016-02-10)
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  • Table of Contents — September 24, 2014, 6 (255) | Science Translational Medicine
    Lee Patricia de Almeida Feng Lan Sebastian Diecke Paul W Burridge Joseph D Gold Daria Mochly Rosen Joseph C Wu Science Translational Medicine 24 Sep 2014 255ra130 The decrease of function in the ALDH2 2 genotype disrupts an important cardioprotective oxidative stress regulatory circuit thus increasing cardiac cell death after ischemic insult Editor s Summary Abstract Full Text PDF Clinical recovery from surgery correlates with single cell immune signatures By Brice Gaudillière Gabriela K Fragiadakis Robert V Bruggner Monica Nicolau Rachel Finck Martha Tingle Julian Silva Edward A Ganio Christine G Yeh William J Maloney James I Huddleston Stuart B Goodman Mark M Davis Sean C Bendall Wendy J Fantl Martin S Angst Garry P Nolan Science Translational Medicine 24 Sep 2014 255ra131 Single cell mass cytometry revealed immune correlates of patient associated variability in surgical recovery Editor s Summary Abstract Full Text PDF Treatment of heterotopic ossification through remote ATP hydrolysis By Jonathan R Peterson Sara De La Rosa Oluwatobi Eboda Katherine E Cilwa Shailesh Agarwal Steven R Buchman Paul S Cederna Chuanwu Xi Michael D Morris David N Herndon Wenzhong Xiao Ronald G Tompkins Paul H Krebsbach Stewart C Wang Benjamin Levi Science Translational Medicine 24 Sep 2014 255ra132 Heterotopic ossification induced by injuries and burns is mediated by signaling through the SMAD pathway and can be targeted with topical apyrase Editor s Summary Abstract Full Text PDF Closed loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury By Nikolaus Wenger Eduardo Martin Moraud Stanisa Raspopovic Marco Bonizzato Jack DiGiovanna Pavel Musienko Manfred Morari Silvestro Micera Grégoire Courtine Science Translational Medicine 24 Sep 2014 255ra133 Closed loop neuromodulation of spinal sensorimotor circuits allows high fidelity control over leg movements in paralyzed rats Editor s Summary Abstract Full Text PDF Editors Choice Urothelial Carcinogenesis A Tale of Two Cells By Bishoy M Faltas Science Translational Medicine 24 Sep 2014 255ec163 A study in a mouse model of chemical induced bladder cancer shows different cells of origin for different histopathologiocal types of urothelial carcinoma Full Text A Cancer Drug Promotes Hair Growth By Marcela V Maus Science Translational Medicine 24 Sep 2014 255ec164 Blockade of cytokine production with JAK targeted drugs promotes hair growth in mice and humans with alopecia areata Full Text Tackling the Persistent Effects of Concussion By Daniel K Nishijima Science Translational Medicine 24 Sep 2014 255ec165 Transcranial magnetic stimulation improved symptoms in subjects experiencing persistent negative effects after a concussion Full Text Picturing Inflammation in Blood Vessels By Eric C Stecker Science Translational Medicine 24 Sep 2014 255ec166 Investigators have successfully imaged the dynamics of leukocyte infiltration into atherosclerotic plaques in humans Full Text Retraction Retraction of the Letter Comment on CD4 T cell autoimmunity to hypocretin orexin and cross reactivity to a 2009 H1N1 influenza A epitope in narcolepsy By Robbert van der Most Martine Wettendorff Bruce Innis Emmanuel Hanon Science Translational Medicine 24 Sep 2014 255rt2 Full Text PDF More From Science Translational Medicine Current Table of Contents Archive

    Original URL path: http://stm.sciencemag.org/content/6/255 (2016-02-10)
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  • Table of Contents — October 01, 2014, 6 (256) | Science Translational Medicine
    Full Text PDF Histone deacetylase inhibition rescues structural and functional brain deficits in a mouse model of Kabuki syndrome By Hans T Bjornsson Joel S Benjamin Li Zhang Jacqueline Weissman Elizabeth E Gerber Yi Chun Chen Rebecca G Vaurio Michelle C Potter Kasper D Hansen Harry C Dietz Science Translational Medicine 01 Oct 2014 256ra135 A neurogenesis defect in a mouse model of Kabuki syndrome can be ameliorated postnatally using histone deacetylase inhibitors Editor s Summary Abstract Full Text PDF A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation By Marianne Delville Tara K Sigdel Changli Wei Jing Li Szu Chuan Hsieh Alessia Fornoni George W Burke Patrick Bruneval Maarten Naesens Annette Jackson Nada Alachkar Guillaume Canaud Christophe Legendre Dany Anglicheau Jochen Reiser Minnie M Sarwal Science Translational Medicine 01 Oct 2014 256ra136 Pretransplant antibodies particularly anti CD40 correlate with risk of recurrent focal segmental glomerulosclerosis after kidney transplant Editor s Summary Abstract Full Text PDF Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans By Kazu Kobayakawa Hiromi Kumamaru Hirokazu Saiwai Kensuke Kubota Yasuyuki Ohkawa Junji Kishimoto Kazuya Yokota Ryosuke Ideta Keiichiro Shiba Hidetoshi Tozaki Saitoh Kazuhide Inoue Yukihide Iwamoto Seiji Okada Science Translational Medicine 01 Oct 2014 256ra137 Acute hyperglycemia exacerbates poor functional outcomes after spinal cord injury through overactivation of microglia in mice and in a human cohort Editor s Summary Abstract Full Text PDF Editors Choice Synthetic Lethality Drug Repurposing with a Difference By Anshu Bhardwaj Science Translational Medicine 01 Oct 2014 256ec167 Gene compound synthetic lethality can be used to determine genetic determinants of antibiotic resistance in Mycobacterium tuberculosis Full Text Too Much of a Good Thing By Charles S Dela Cruz Science Translational Medicine 01 Oct 2014 256ec168 Mutations in an inflammasome protein lead to systemic

    Original URL path: http://stm.sciencemag.org/content/6/256 (2016-02-10)
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  • Table of Contents — October 08, 2014, 6 (257) | Science Translational Medicine
    Genotype based treatment of type 2 diabetes with an α 2A adrenergic receptor antagonist By Yunzhao Tang Annika S Axelsson Peter Spégel Lotta E Andersson Hindrik Mulder Leif C Groop Erik Renström Anders H Rosengren Science Translational Medicine 08 Oct 2014 257ra139 The α 2A adrenergic receptor antagonist yohimbine improves insulin secretion in type 2 diabetics carrying the ADRA2A risk variant Editor s Summary Abstract Full Text PDF Reports An osseointegrated human machine gateway for long term sensory feedback and motor control of artificial limbs By Max Ortiz Catalan Bo Håkansson Rickard Brånemark Science Translational Medicine 08 Oct 2014 257re6 An osseointegrated interface allowed long term stable and bidirectional communication between robotic prostheses and implanted neuromuscular electrodes for intuitive control with sensory feedback in one patient Editor s Summary Abstract Full Text PDF Noninvasive brain computer interface enables communication after brainstem stroke By Eric W Sellers David B Ryan Christopher K Hauser Science Translational Medicine 08 Oct 2014 257re7 An individual locked in by a brainstem stroke was able to communicate using noninvasive brain computer interface technology Editor s Summary Abstract Full Text PDF Editors Choice A Bug in the System for Artificial Sweeteners By Saptarsi M Haldar Science Translational Medicine 08 Oct 2014 257ec170 Artificial sweeteners impair glucose tolerance in mice and humans by affecting the gut microbiome Full Text Translational Tectonics for Stents By Kumaran Kolandaivelu Science Translational Medicine 08 Oct 2014 257ec171 Measuring the pressure drop caused by a coronary artery occlusion enhances the therapeutic benefits of stent based treatment of stable coronary heart disease Full Text Protecting the Fortress Preventing Metastasis by Neutralizing Niche Homing By Justin D Lathia Science Translational Medicine 08 Oct 2014 257ec172 Multiple myeloma metastasis can be prevented by neutralizing stromal cell derived factor 1 to inhibit tumor cell homing to the

    Original URL path: http://stm.sciencemag.org/content/6/257 (2016-02-10)
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  • Table of Contents — October 15, 2014, 6 (258) | Science Translational Medicine
    Text PDF Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy By S Armando Villalta Wendy Rosenthal Leonel Martinez Amanjot Kaur Tim Sparwasser James G Tidball Marta Margeta Melissa J Spencer Jeffrey A Bluestone Science Translational Medicine 15 Oct 2014 258ra142 Regulatory T cells ameliorate symptoms of muscular dystrophy by suppressing type 1 inflammatory responses in muscle Editor s Summary Abstract Full Text PDF PCSK9 is a critical regulator of the innate immune response and septic shock outcome By Keith R Walley Katherine R Thain James A Russell Muredach P Reilly Nuala J Meyer Jane F Ferguson Jason D Christie Taka aki Nakada Chris D Fjell Simone A Thair Mihai S Cirstea John H Boyd Science Translational Medicine 15 Oct 2014 258ra143 Inhibition of PCSK9 function is associated with an increase in pathogen lipid clearance a decrease in the innate immune inflammatory response and an improvement in septic shock clinical outcome Editor s Summary Abstract Full Text PDF Editors Choice Superheroes and Villains of the Heart By Mathieu Lemaire Science Translational Medicine 15 Oct 2014 258ec175 A cardiac specific long noncoding RNA plays a critical role in protecting humans and mice from heart failure Full Text Outrunning Depression By Anne Schaefer Science Translational Medicine 15 Oct 2014 258ec176 Exercise induced kynurenine metabolism in skeletal muscle protects mice against stress induced depression Full Text Artificial Spleen Sorts Things Out By Matthias Stephan Science Translational Medicine 15 Oct 2014 258ec177 The biospleen a microfluidic device with magnetic nanoparticles removes pathogens from infected blood ex vivo within hours Full Text Keeping the Flow Going FGFR1 Protects Vascular Patency by Inhibiting Occlusive Neointimal Hyperplasia By Vipul Chitalia Science Translational Medicine 15 Oct 2014 258ec178 FGFR1 regulates TGFβ signaling to block the neointimal formation a lesion responsible for several occlusive vascular diseases Full

    Original URL path: http://stm.sciencemag.org/content/6/258 (2016-02-10)
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  • Table of Contents — October 22, 2014, 6 (259) | Science Translational Medicine
    of cytokinesis By Yo Matsuo Jae Hyun Park Takashi Miyamoto Shinji Yamamoto Shoji Hisada Houda Alachkar Yusuke Nakamura Science Translational Medicine 22 Oct 2014 259ra145 TOPK inhibitor kills cancer cells by causing a cytokinesis defect and promotes tumor regression in mouse models Editor s Summary Abstract Full Text PDF Imaging Enterobacteriaceae infection in vivo with 18 F fluorodeoxysorbitol positron emission tomography By Edward A Weinstein Alvaro A Ordonez Vincent P DeMarco Allison M Murawski Supriya Pokkali Elizabeth M MacDonald Mariah Klunk Ronnie C Mease Martin G Pomper Sanjay K Jain Science Translational Medicine 22 Oct 2014 259ra146 2 18 F Fluorodeoxysorbitol a synthetic PET probe can be used to rapidly sensitively and specifically image Gram negative bacterial infections in animals Editor s Summary Abstract Full Text PDF Editors Choice Short Circuiting Mitochondria Leads to Improvement in Mouse Models of Diabetes By Chester L Drum Science Translational Medicine 22 Oct 2014 259ec179 Diabetic symptoms can be improved in mice through mitochondrial decoupling with a currently approved anthelmintic drug Full Text Elbow Grease By Kara L Spiller Science Translational Medicine 22 Oct 2014 259ec180 A biomimetic strategy to bind hyaluronic acid to joint and eye surfaces effectively increases lubrication Full Text Treating Asthma Divide and Conquer By Jie Sun Science Translational Medicine 22 Oct 2014 259ec181 Epithelial interleukin 25 expression segregates asthma subgroups that may respond to inhaled corticosteroid Full Text Stem Cell Therapy for Diabetes Comes of Age By Paul J Tesar Science Translational Medicine 22 Oct 2014 259ec182 An optimized protocol enables the rapid generation of mature functional human β cells from pluripotent stem cells Full Text Sequence Specific Antibiotics By Ephraim L Tsalik Science Translational Medicine 22 Oct 2014 259ec183 Modified CRISPR Cas nucleases target pathogens or resistance genes for sequence specific destruction Full Text More From Science Translational

    Original URL path: http://stm.sciencemag.org/content/6/259 (2016-02-10)
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