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  • Table of Contents — October 29, 2014, 6 (260) | Science Translational Medicine
    An in vivo concentration effect relationship for the malaria drug piperaquine can be used for translational simulations of expected therapeutic outcomes in vulnerable populations Editor s Summary Abstract Full Text PDF Endoscopic molecular imaging of human bladder cancer using a CD47 antibody By Ying Pan Jens Peter Volkmer Kathleen E Mach Robert V Rouse Jen Jane Liu Debashis Sahoo Timothy C Chang Thomas J Metzner Lei Kang Matt van de Rijn Eila C Skinner Sanjiv S Gambhir Irving L Weissman Joseph C Liao Science Translational Medicine 29 Oct 2014 260ra148 Fluorescently labeled CD47 antibody is an endoscopic molecular imaging agent to diagnose human bladder cancer Editor s Summary Abstract Full Text PDF Clinical translation of an ultrasmall inorganic optical PET imaging nanoparticle probe By Evan Phillips Oula Penate Medina Pat B Zanzonico Richard D Carvajal Pauliah Mohan Yunpeng Ye John Humm Mithat Gönen Hovanes Kalaigian Heiko Schöder H William Strauss Steven M Larson Ulrich Wiesner Michelle S Bradbury Science Translational Medicine 29 Oct 2014 260ra149 Ultrasmall inorganic hybrid optical PET imaging particles were found to be safe and physiologically stable in patients with melanoma Editor s Summary Abstract Full Text PDF Affinity based design of a synthetic universal reversal agent for heparin anticoagulants By Rajesh A Shenoi Manu Thomas Kalathottukaren Richard J Travers Benjamin F L Lai A Louise Creagh Dirk Lange Kai Yu Marie Weinhart Ben H Chew Caigan Du Donald E Brooks Cedric J Carter James H Morrissey Charles A Haynes Jayachandran N Kizhakkedathu Science Translational Medicine 29 Oct 2014 260ra150 A safe synthetic anticoagulant reversal agent based on a dendritic polymer is effective against all the clinical heparin anticoagulants and may be a treatment for bleeding in high risk surgical procedures Editor s Summary Abstract Full Text PDF Editors Choice BETing on the Therapeutic Potential of Super Enhancers By Ebru Erbay Science Translational Medicine 29 Oct 2014 260ec184 Antagonism of the bromodomain and extraterminal domain BET family of epigenetic reader and transcription cofactors represents a therapeutic opportunity in atherosclerosis Full Text Can Milk Do Harm By David E Gerber Science Translational Medicine 29 Oct 2014 260ec185 Lactose intolerance may protect against lung breast and ovarian cancers Full Text The Brain Ground Zero in Hepatic Insulin Resistance By Elvin Price Science Translational Medicine 29 Oct 2014 260ec186 Disrupted insulin signaling in the brain alters amino acid metabolism in the liver resulting in peripheral insulin resistance Full Text Too Much of a Good Thing Finding an IL1B Polymorphism That Increases Tuberculosis Susceptibility By Henrique Serezani Science Translational Medicine 29 Oct 2014 260ec187 Polymorphism in an IL1B allele determines disease progression and severity in tuberculosis Full Text Lessons from the Ketchup Bottle By Nathan J White Science Translational Medicine 29 Oct 2014 260ec188 Shear thinning composite nanogels can be used for hemorrhage control in animals Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff

    Original URL path: http://stm.sciencemag.org/content/6/260 (2016-02-10)
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  • Table of Contents — November 05, 2014, 6 (261) | Science Translational Medicine
    261ra152 Single cell pharmacokinetic analysis of a fluorescent eribulin derivative in vivo revealed drug resistance mediated by MDR1 driven efflux which was overcome by a nanoencapsulated MDR1 inhibitor Editor s Summary Abstract Full Text PDF A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes boosts and sustains functional HCV specific T cell memory By Leo Swadling Stefania Capone Richard D Antrobus Anthony Brown Rachel Richardson Evan W Newell John Halliday Christabel Kelly Dan Bowen Joannah Fergusson Ayako Kurioka Virginia Ammendola Mariarosaria Del Sorbo Fabiana Grazioli Maria Luisa Esposito Loredana Siani Cinzia Traboni Adrian Hill Stefano Colloca Mark Davis Alfredo Nicosia Riccardo Cortese Antonella Folgori Paul Klenerman Eleanor Barnes Science Translational Medicine 05 Nov 2014 261ra153 A prime boost HCV vaccine strategy induces durable and broad T cell responses characteristic of those associated with viral control Editor s Summary Abstract Full Text PDF Therapeutic bispecific antibodies cross the blood brain barrier in nonhuman primates By Y Joy Yu Jasvinder K Atwal Yin Zhang Raymond K Tong Kristin R Wildsmith Christine Tan Nga Bien Ly Maria Hersom Janice A Maloney William J Meilandt Daniela Bumbaca Kapil Gadkar Kwame Hoyte Wilman Luk Yanmei Lu James A Ernst Kimberly Scearce Levie Jessica A Couch Mark S Dennis Ryan J Watts Science Translational Medicine 05 Nov 2014 261ra154 Bispecific antibodies engineered to both bind to the primate transferrin receptor and inhibit β secretase are taken up by the nonhuman primate brain and reduce brain β amyloid Editor s Summary Abstract Full Text PDF Editors Choice Studying the Soil for Metastatic Seeds By Bishoy M Faltas Science Translational Medicine 05 Nov 2014 261ec189 A new bioengineered scaffold model can be used for studying tumor microenvironments Full Text CAR T Cells Advance to the Next Level By Marcela V Maus Science Translational Medicine 05 Nov 2014 261ec190 CAR T cells redirected to CD19 in association with chimeric antigen receptors show potency in leukemia Full Text Exploring the Link Between Traumatic Brain Injury and Dementia By Daniel K Nishijima Science Translational Medicine 05 Nov 2014 261ec191 In older people experiencing an injury to the brain increases the risk of developing dementia Full Text Lost Rhythms and the Failing Heart By Eric C Stecker Science Translational Medicine 05 Nov 2014 261ec192 Acute heart failure episodes place strain on heart myofibroblasts leading to arrhythmias and sudden cardiac death Full Text Podcast Science Translational Medicine Podcast 05 November 2014 By Eleanor Barnes Annalisa VanHook Science Translational Medicine 05 Nov 2014 261pc5 Eleanor Barnes describes how a prime boost vaccine strategy induces T cell responses that are important for HCV control Abstract Erratum Erratum for the Research Article Identification of a New Modulator of the Intercalated Disc in a Zebrafish Model of Arrhythmogenic Cardiomyopathy by A Asimaki S Kapoor E Plovie A Karin Arndt E Adams Z Liu C A James D P Judge H Calkins J Churko J C Wu C A MacRae A G Kléber J E Saffitz Science Translational Medicine 05 Nov 2014 261er6 Full

    Original URL path: http://stm.sciencemag.org/content/6/261 (2016-02-10)
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  • Table of Contents — November 12, 2014, 6 (262) | Science Translational Medicine
    Sommer Science Translational Medicine 12 Nov 2014 262ra156 Collateral sensitivity profiles of drug evolved lineages can be used to predict drug combinations that suppress evolution of resistance Editor s Summary Abstract Full Text PDF Semen enhances HIV infectivity and impairs the antiviral efficacy of microbicides By Onofrio Zirafi Kyeong Ae Kim Nadia R Roan Silvia F Kluge Janis A Müller Shibo Jiang Benjamin Mayer Warner C Greene Frank Kirchhoff Jan Münch Science Translational Medicine 12 Nov 2014 262ra157 Endogenous amyloids in semen impair the antiretroviral efficacy of drugs targeting HIV directly but do not impair maraviroc which targets the cellular CCR5 receptor Editor s Summary Abstract Full Text PDF State of the Art Review Prevention of preterm birth Harnessing science to address the global epidemic By Craig E Rubens Yoel Sadovsky Louis Muglia Michael G Gravett Eve Lackritz Courtney Gravett Science Translational Medicine 12 Nov 2014 262sr5 This review summarizes the state of research on the causes of preterm birth potential targets for prevention and translational challenges and opportunities Abstract Full Text PDF Editors Choice Cholesterol Therapy That s Not Chopped Liver By Anshu Bhardwaj Science Translational Medicine 12 Nov 2014 262ec193 The cholesterol drug ezetimibe significantly reduced liver disease in mice fed with a high fat diet Full Text A Tug of War in the Periphery By Vipul Chitalia Science Translational Medicine 12 Nov 2014 262ec194 The metabolic syndrome a strong risk factor for peripheral artery disease increases the antiangiogenic VEGF A 165b isoform impeding the development of new blood vessels in ischemic limbs Full Text Biospleen for Removing Bad Humors in Sepsis By Charles S Dela Cruz Science Translational Medicine 12 Nov 2014 262ec195 A biospleen may filter blood from septic patients to remove circulating pathogens and their inflammatory by products Full Text Tau Chopping Enzyme Adds Fuel

    Original URL path: http://stm.sciencemag.org/content/6/262 (2016-02-10)
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  • Table of Contents — November 19, 2014, 6 (263) | Science Translational Medicine
    Nilsson Hans Hebert Bruce T Volpe Betty Diamond Sven Pettersson Science Translational Medicine 19 Nov 2014 263ra158 The intestinal microbiota helps to maintain the integrity of the blood brain barrier in fetal and adult mice Editor s Summary Abstract Full Text PDF Metformin as adjunct antituberculosis therapy By Amit Singhal Liu Jie Pavanish Kumar Gan Suay Hong Melvin Khee Shing Leow Bhairav Paleja Liana Tsenova Natalia Kurepina Jinmiao Chen Francesca Zolezzi Barry Kreiswirth Michael Poidinger Cynthia Chee Gilla Kaplan Yee Tang Wang Gennaro De Libero Science Translational Medicine 19 Nov 2014 263ra159 Metformin can be repurposed as host directed therapy for tuberculosis Editor s Summary Abstract Full Text PDF Rational design of small molecules as vaccine adjuvants By Tom Y H Wu Manmohan Singh Andrew T Miller Ennio De Gregorio Francesco Doro Ugo D Oro David A G Skibinski M Lamine Mbow Simone Bufali Ann E Herman Alex Cortez Yongkai Li Bishnu P Nayak Elaine Tritto Christophe M Filippi Gillis R Otten Luis A Brito Elisabetta Monaci Chun Li Susanna Aprea Sara Valentini Samuele Calabrό Donatello Laera Brunella Brunelli Elena Caproni Padma Malyala Rekha G Panchal Travis K Warren Sina Bavari Derek T O Hagan Michael P Cooke Nicholas M Valiante Science Translational Medicine 19 Nov 2014 263ra160 Small molecule immune potentiators can be engineered to be potent adjuvants with localized innate immune activation and short in vivo residence times Editor s Summary Abstract Full Text PDF A combination therapy for KRAS driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin By Yifeng Xia Yi Liang Liu Yonghua Xie Wei Zhu Francisco Guerra Shen Shen Narayana Yeddula Wolfgang Fischer William Low Xiaoying Zhou Yonghui Zhang Eric Oldfield Inder M Verma Science Translational Medicine 19 Nov 2014 263ra161 Lipophilic bisphosphonates combined with rapamycin inhibit the growth of KRAS mutant lung adenocarcinomas in mouse models Editor s Summary Abstract Full Text PDF Editors Choice Monkeying Around with LDL Receptor Levels By Saptarsi M Haldar Science Translational Medicine 19 Nov 2014 263ec197 A nuclear receptor signaling pathway s effect on LDL receptor and cholesterol homeostasis is strikingly different between mice and monkeys Full Text Inhaling H 2 ope By Kumaran Kolandaivelu Science Translational Medicine 19 Nov 2014 263ec198 Inhaled hydrogen may improve survival and neurological outcomes following cardiac arrest Full Text Finding a Needle in a Myeloid Haystack By Justin D Lathia Science Translational Medicine 19 Nov 2014 263ec199 Analysis of the myeloid compartment reveals a rare intratumoral dendritic cell population that stimulates cytotoxic T cells in multiple tumor types Full Text Heating Up The Genetics of Febrile Seizures By Heather C Mefford Science Translational Medicine 19 Nov 2014 263ec200 An array of rare and common genetic variants is associated with the fever related seizures typically seen in children Full Text Shaping Up with the Gut Microbiota By June L Round Science Translational Medicine 19 Nov 2014 263ec201 Host genetics influences the composition of the gut microbiota and reveals a family of bacteria that may prevent weight gain Full Text Podcast Science Translational Medicine

    Original URL path: http://stm.sciencemag.org/content/6/263 (2016-02-10)
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  • Table of Contents — November 26, 2014, 6 (264) | Science Translational Medicine
    Zurab Siprashvili Andrea Tichy Jiang Li Mohammed Ameen John Hawkins Susie Lee Lingjie Li Aaron Schwertschkow Gerhard Bauer Leszek Lisowski Mark A Kay Seung K Kim Alfred T Lane Marius Wernig Anthony E Oro Science Translational Medicine 26 Nov 2014 264ra163 Patient specific iPSCs were derived corrected and differentiated into human skin grafts for the treatment of recessive dystrophic epidermolysis bullosa Editor s Summary Abstract Full Text PDF Induced pluripotent stem cells from human revertant keratinocytes for the treatment of epidermolysis bullosa By Noriko Umegaki Arao Anna M G Pasmooij Munenari Itoh Jane E Cerise Zongyou Guo Brynn Levy Antoni Gostyński Lisa R Rothman Marcel F Jonkman Angela M Christiano Science Translational Medicine 26 Nov 2014 264ra164 Epidermolysis bullosa patient specific iPSCs were generated from spontaneously corrected revertant keratinocytes for skin reconstitution Editor s Summary Abstract Full Text PDF Genetically corrected iPSCs as cell therapy for recessive dystrophic epidermolysis bullosa By Daniel Wenzel Jonathan Bayerl Alexander Nyström Leena Bruckner Tuderman Arabella Meixner Josef M Penninger Science Translational Medicine 26 Nov 2014 264ra165 iPSCs derived from fibroblasts with mutant type VII collagen were genetically corrected and used as cell therapy in mice with recessive dystrophic epidermolysis bullosa Editor s Summary Abstract Full Text PDF Editors Choice Memories on the Clock A Frequent Flyer s Nightmare By Anne Schaefer Science Translational Medicine 26 Nov 2014 264ec202 Disrupting circadian rhythms without altering the neural circuits that make up the clock itself impairs recognition and spatial memory Full Text Tunneling Through Cell Walls By Matthias Stephan Science Translational Medicine 26 Nov 2014 264ec203 Carbon nanotubes spontaneously insert into the membranes of living cells to form tiny pores that transport DNA water and ions in a controlled manner Full Text Crowdsourcing Disease Prognosis By Ephraim L Tsalik Science Translational Medicine 26 Nov 2014 264ec204 Opening

    Original URL path: http://stm.sciencemag.org/content/6/264 (2016-02-10)
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  • Table of Contents — December 03, 2014, 6 (265) | Science Translational Medicine
    Kim Gwendolyn Marriner Veronique Dartois Charles Scanga Christopher Janssen Jing Wang Edwin Klein Sang Nae Cho Clifton E Barry III JoAnne L Flynn Science Translational Medicine 03 Dec 2014 265ra167 PET CT imaging in macaques and humans with TB shows a beneficial therapeutic response to linezolid and a new oxazolidinone antibiotic AZD5847 Editor s Summary Abstract Full Text PDF Effectiveness of exome and genome sequencing guided by acuity of illness for diagnosis of neurodevelopmental disorders By Sarah E Soden Carol J Saunders Laurel K Willig Emily G Farrow Laurie D Smith Josh E Petrikin Jean Baptiste LePichon Neil A Miller Isabelle Thiffault Darrell L Dinwiddie Greyson Twist Aaron Noll Bryce A Heese Lee Zellmer Andrea M Atherton Ahmed T Abdelmoity Nicole Safina Sarah S Nyp Britton Zuccarelli Ingrid A Larson Ann Modrcin Suzanne Herd Mitchell Creed Zhaohui Ye Xuan Yuan Robert A Brodsky Stephen F Kingsmore Science Translational Medicine 03 Dec 2014 265ra168 Molecular diagnosis of pediatric neurodevelopmental disorders by genomic sequencing is frequently informative and cost effective and can affect clinical care Editor s Summary Abstract Full Text PDF Inhibition of LSD1 reduces herpesvirus infection shedding and recurrence by promoting epigenetic suppression of viral genomes By James M Hill Debra C Quenelle Rhonda D Cardin Jodi L Vogel Christian Clement Fernando J Bravo Timothy P Foster Marta Bosch Marce Priya Raja Jennifer S Lee David I Bernstein Philip R Krause David M Knipe Thomas M Kristie Science Translational Medicine 03 Dec 2014 265ra169 Epigenetic suppression of herpes simplex virus demonstrates an approach to control persistent viruses Editor s Summary Abstract Full Text PDF State of the Art Review Wound repair and regeneration Mechanisms signaling and translation By Sabine A Eming Paul Martin Marjana Tomic Canic Science Translational Medicine 03 Dec 2014 265sr6 The combination of an advanced scientific understanding of tissue repair and regeneration and the identification of knowledge gaps and the limitations of past clinical trials will provide a strong basis to advance viable clinical approaches for treating patients with wound healing pathologies Abstract Full Text PDF Editors Choice Watch Your Leftovers Remnant Cholesterol Brings Oversized Risk to Cardiovascular Health By Chester L Drum Science Translational Medicine 03 Dec 2014 265ec205 A large scale analysis of a Copenhagen cohort reveals mediators of cardiovascular risk for obese individuals Full Text The Clot Thickens By Kara L Spiller Science Translational Medicine 03 Dec 2014 265ec206 Ultra deformable synthetic platelets stop bleeding in minutes Full Text Filled with Evil Molecular Signatures of Tumor Associated Immune Cells By Jie Sun Science Translational Medicine 03 Dec 2014 265ec207 Molecular profiling unveils how monocytes and macrophages in human renal cancers contribute to tumor progression Full Text Morphing Cell Identity to Treat Diabetes By Paul J Tesar Science Translational Medicine 03 Dec 2014 265ec208 An optimized protocol enables in vivo conversion of pancreatic acinar cells to functional pancreatic beta cells with implications for treating diabetes Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission

    Original URL path: http://stm.sciencemag.org/content/6/265 (2016-02-10)
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  • Table of Contents — December 10, 2014, 6 (266) | Science Translational Medicine
    Abstract Full Text PDF Human limbal biopsy derived stromal stem cells prevent corneal scarring By Sayan Basu Andrew J Hertsenberg Martha L Funderburgh Michael K Burrow Mary M Mann Yiqin Du Kira L Lathrop Fatima N Syed Picard Sheila M Adams David E Birk James L Funderburgh Science Translational Medicine 10 Dec 2014 266ra172 Human stromal stem cells isolated from limbal biopsies prevented corneal scarring in a murine model of corneal wounding Editor s Summary Abstract Full Text PDF White matter changes linked to visual recovery after nerve decompression By David A Paul Elon Gaffin Cahn Eric B Hintz Giscard J Adeclat Tong Zhu Zoë R Williams G Edward Vates Bradford Z Mahon Science Translational Medicine 10 Dec 2014 266ra173 Rapid remyelination is a major contributor to the normalization of vision after surgical removal of pituitary tumors in human patients and decompression of the optic chiasm Editor s Summary Abstract Full Text PDF Editors Choice An Armored CAR for Leukemia Treatment By David E Gerber Science Translational Medicine 10 Dec 2014 266ec209 Chimeric antigen receptor modified T cells show promise for leukemia treatment Full Text T rains Derailed in Fat Depots Cause Insulin Resistance By Elvin Price Science Translational Medicine 10 Dec 2014 266ec210 T lymphocytes infiltrate adipose tissue and correlate with systemic inflammation and insulin resistance Full Text The Advantages of Being a Superantigen By Henrique Serezani Science Translational Medicine 10 Dec 2014 266ec211 Protein A mediates Staphylococcus aureus immune evasion by redirecting specific antibody production Full Text Time to Get Personal with CPR By Nathan J White Science Translational Medicine 10 Dec 2014 266ec212 Real time physiological guidance of CPR improves outcomes from experimental cardiac arrest Full Text Erratum Erratum for the Research Article The gut microbiota influences blood brain barrier permeability in mice by V Braniste M

    Original URL path: http://stm.sciencemag.org/content/6/266 (2016-02-10)
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  • Table of Contents — December 17, 2014, 6 (267) | Science Translational Medicine
    cells from dystrophic mice By Stefano Biressi Elen H Miyabara Suchitra D Gopinath Poppy M M Carlig Thomas A Rando Science Translational Medicine 17 Dec 2014 267ra176 A Wnt TGFβ2 signaling pathway modulates stem cell dysfunction in muscles of dystrophic mice Editor s Summary Abstract Full Text PDF Editors Choice ER Mitochondrial Communication Gets Stressful By Ebru Erbay Science Translational Medicine 17 Dec 2014 267ec213 An increase in contacts between the endoplasmic reticulum and mitochondria with a concomitant influx of calcium ions into liver cells may contribute to obesity induced metabolic syndrome Full Text Checkpoint Therapy to the Rescue By Bishoy M Faltas Science Translational Medicine 17 Dec 2014 267ec214 Nivolumab had substantial activity and was safe in patients with heavily treated relapsed or refractory Hodgkin s lymphoma Full Text T Cells Through the Age s By Marcela V Maus Science Translational Medicine 17 Dec 2014 267ec215 T cell subset distribution throughout the human life span depends on differentiation state and tissue localization Full Text Sprouting Neurological Function By Daniel K Nishijima Science Translational Medicine 17 Dec 2014 267ec216 Blocking the action of a nerve growth inhibitor that accumulates after spinal cord injury promotes better recovery of neural function Full Text Growing a New Heart from the Old One By Eric C Stecker Science Translational Medicine 17 Dec 2014 267ec217 Genetic investigations shed light on how heart muscle may regenerate Full Text Erratum Erratum for the Research Article Human COL7A1 corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa by V Sebastiano H H Zhen B Haddad E Bashkirova S P Melo P Wang T L Leung Z Siprashvili A Tichy J Li M Ameen J Hawkins S Lee L Li A Schwertschkow G Bauer L Lisowski M A Kay S K Kim A T Lane

    Original URL path: http://stm.sciencemag.org/content/6/267 (2016-02-10)
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