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  • Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1 | Science Translational Medicine
    Molecular Medicine University of Bristol BS8 1TH Bristol UK Find this author on Google Scholar Find this author on PubMed Search for this author on this site Christoph Biskup Biomolecular Photonics Group Jena University Hospital D 07740 Jena Germany Find this author on Google Scholar Find this author on PubMed Search for this author on this site Senta M Kapnick Genetic Disease Research Branch National Human Genome Research Institute National Institutes of Health Bethesda MD 20892 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Katherine Verbist Department of Oncology St Jude Children s Research Hospital Memphis TN 38105 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Paige Tedrick Department of Oncology St Jude Children s Research Hospital Memphis TN 38105 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Pamela L Schwartzberg Genetic Disease Research Branch National Human Genome Research Institute National Institutes of Health Bethesda MD 20892 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Cosima T Baldari Department of Life Sciences University of Siena 53100 Siena Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Ignacio Rubio Integrated Research and Treatment Center Center for Sepsis Control and Care and Institute of Molecular Cell Biology Center for Molecular Biomedicine Jena University Hospital D 07745 Jena Germany Find this author on Google Scholar Find this author on PubMed Search for this author on this site Kim E Nichols Department of Oncology St Jude Children s Research Hospital Memphis TN 38105 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Andrew L Snow Department of Pharmacology and Molecular Therapeutics Uniformed Services University of the Health Sciences Bethesda MD 20814 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Gianluca Baldanzi Department of Translational Medicine and Institute for Research and Cure of Autoimmune Diseases University of Piemonte Orientale 28100 Novara Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Andrea Graziani Department of Translational Medicine and Institute for Research and Cure of Autoimmune Diseases University of Piemonte Orientale 28100 Novara Italy School of Medicine University Vita e Salute San Raffaele 20132 Milan Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF Log in to view full text Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Join Subscribe Purchase Article Activate Member Account Renew Subscription Recommend a subscription to your library Help for librarians Science Translational Medicine Vol 8 Issue

    Original URL path: http://stm.sciencemag.org/content/8/321/321ra7.full (2016-02-10)
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  • Cord blood monocyte–derived inflammatory cytokines suppress IL-2 and induce nonclassic “TH2-type” immunity associated with development of food allergy | Science Translational Medicine
    Royal Children s Hospital Parkville Victoria 3052 Australia Find this author on Google Scholar Find this author on PubMed Search for this author on this site Leonard C Harrison Walter and Eliza Hall Institute of Medical Research Parkville Victoria 3052 Australia The University of Melbourne Parkville Victoria 3010 Australia Find this author on Google Scholar Find this author on PubMed Search for this author on this site Peter Vuillermin The University of Melbourne Parkville Victoria 3010 Australia Barwon Health Geelong Victoria 3220 Australia Deakin University Geelong Victoria 3216 Australia Murdoch Childrens Research Institute Royal Children s Hospital Parkville Victoria 3052 Australia Find this author on Google Scholar Find this author on PubMed Search for this author on this site on behalf of the BIS Investigator Group Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the abstract View Full Text Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Join Subscribe Purchase Article Activate Member Account Renew Subscription Recommend a subscription to your library Help for librarians Fighting food allergy For people with food allergies a slice of pizza or a peanut butter sandwich can be deadly Yet despite the increasing prevalence of food allergy little is known as to the immunological causes Now Zhang et al report that infants who later developed food allergy had altered immunity at birth Cord blood from these infants had more monocytes compared with CD4 T cells and decreased numbers of regulatory T cells Moreover the monocytes from food allergic infants secreted more inflammatory cytokines than those from healthy infants These cytokines suppressed interleukin 2 IL 2 expression by CD4 T cells and skewed differentiation of these cells to a nonclassical T helper 2 T H 2 phenotype Anti inflammatory strategies should therefore be considered in preventing food allergy in these individuals Abstract Food allergy is a major health burden in early childhood Infants who develop food allergy display a proinflammatory immune profile in cord blood but how this is related to interleukin 4 IL 4 T helper 2 T H 2 type immunity characteristic of allergy is unknown In a general population derived birth cohort we found that in infants who developed food allergy cord blood displayed a higher monocyte to CD4 T cell ratio and a lower proportion of natural regulatory T cell nT reg in relation to duration of labor CD14 monocytes of food allergic infants secreted higher amounts of inflammatory cytokines IL 1β IL 6 and tumor necrosis factor α in response to lipopolysaccharide In the presence of the mucosal cytokine transforming growth factor β these inflammatory cytokines suppressed IL 2 expression by CD4 T cells In the absence of IL 2 inflammatory cytokines decreased the number of activated nT reg and diverted the differentiation of both nT reg and naïve CD4 T cells toward an IL 4 expressing nonclassical T H 2 phenotype These findings provide a mechanistic

    Original URL path: http://stm.sciencemag.org/content/8/321/321ra8 (2016-02-10)
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  • Cord blood monocyte–derived inflammatory cytokines suppress IL-2 and induce nonclassic “TH2-type” immunity associated with development of food allergy | Science Translational Medicine
    this site Mimi LK Tang The University of Melbourne Parkville Victoria 3010 Australia Murdoch Childrens Research Institute Royal Children s Hospital Parkville Victoria 3052 Australia Find this author on Google Scholar Find this author on PubMed Search for this author on this site Katrina J Allen The University of Melbourne Parkville Victoria 3010 Australia Murdoch Childrens Research Institute Royal Children s Hospital Parkville Victoria 3052 Australia Find this author on Google Scholar Find this author on PubMed Search for this author on this site Anne Louise Ponsonby The University of Melbourne Parkville Victoria 3010 Australia Murdoch Childrens Research Institute Royal Children s Hospital Parkville Victoria 3052 Australia Find this author on Google Scholar Find this author on PubMed Search for this author on this site Leonard C Harrison Walter and Eliza Hall Institute of Medical Research Parkville Victoria 3052 Australia The University of Melbourne Parkville Victoria 3010 Australia Find this author on Google Scholar Find this author on PubMed Search for this author on this site Peter Vuillermin The University of Melbourne Parkville Victoria 3010 Australia Barwon Health Geelong Victoria 3220 Australia Deakin University Geelong Victoria 3216 Australia Murdoch Childrens Research Institute Royal Children s Hospital Parkville Victoria 3052 Australia Find this author on Google Scholar Find this author on PubMed Search for this author on this site on behalf of the BIS Investigator Group Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the editor s summary View Full Text Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Join Subscribe Purchase Article Activate Member Account Renew Subscription Recommend a subscription to your library Help for librarians Fighting food allergy For people with food allergies a slice of pizza or a peanut butter sandwich can be deadly Yet despite the increasing prevalence of food allergy little is known as to the immunological causes Now Zhang et al report that infants who later developed food allergy had altered immunity at birth Cord blood from these infants had more monocytes compared with CD4 T cells and decreased numbers of regulatory T cells Moreover the monocytes from food allergic infants secreted more inflammatory cytokines than those from healthy infants These cytokines suppressed interleukin 2 IL 2 expression by CD4 T cells and skewed differentiation of these cells to a nonclassical T helper 2 T H 2 phenotype Anti inflammatory strategies should therefore be considered in preventing food allergy in these individuals Copyright 2016 American Association for the Advancement of Science Science Translational Medicine Vol 8 Issue 321 13 January 2016 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your

    Original URL path: http://stm.sciencemag.org/content/8/321/321ra8.editor-summary (2016-02-10)
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  • Cord blood monocyte–derived inflammatory cytokines suppress IL-2 and induce nonclassic “TH2-type” immunity associated with development of food allergy | Science Translational Medicine
    Parkville Victoria 3052 Australia Find this author on Google Scholar Find this author on PubMed Search for this author on this site Richard Saffery The University of Melbourne Parkville Victoria 3010 Australia Murdoch Childrens Research Institute Royal Children s Hospital Parkville Victoria 3052 Australia Find this author on Google Scholar Find this author on PubMed Search for this author on this site Mimi LK Tang The University of Melbourne Parkville Victoria 3010 Australia Murdoch Childrens Research Institute Royal Children s Hospital Parkville Victoria 3052 Australia Find this author on Google Scholar Find this author on PubMed Search for this author on this site Katrina J Allen The University of Melbourne Parkville Victoria 3010 Australia Murdoch Childrens Research Institute Royal Children s Hospital Parkville Victoria 3052 Australia Find this author on Google Scholar Find this author on PubMed Search for this author on this site Anne Louise Ponsonby The University of Melbourne Parkville Victoria 3010 Australia Murdoch Childrens Research Institute Royal Children s Hospital Parkville Victoria 3052 Australia Find this author on Google Scholar Find this author on PubMed Search for this author on this site Leonard C Harrison Walter and Eliza Hall Institute of Medical Research Parkville Victoria 3052 Australia The University of Melbourne Parkville Victoria 3010 Australia Find this author on Google Scholar Find this author on PubMed Search for this author on this site Peter Vuillermin The University of Melbourne Parkville Victoria 3010 Australia Barwon Health Geelong Victoria 3220 Australia Deakin University Geelong Victoria 3216 Australia Murdoch Childrens Research Institute Royal Children s Hospital Parkville Victoria 3052 Australia Find this author on Google Scholar Find this author on PubMed Search for this author on this site on behalf of the BIS Investigator Group Search for this author on this site Article Figures Data Info Metrics eLetters PDF Log in to view full text Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Join Subscribe Purchase Article Activate Member Account Renew Subscription Recommend a subscription to your library Help for librarians Science Translational Medicine Vol 8 Issue 321 13 January 2016 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Cord blood monocyte derived inflammatory cytokines suppress IL 2 and induce nonclassic TH2 type immunity associated with development of food allergy Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to

    Original URL path: http://stm.sciencemag.org/content/8/321/321ra8.full (2016-02-10)
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  • Cancer care looks ROSEy | Science Translational Medicine
    on Google Scholar Find this author on PubMed Search for this author on this site Article Info Metrics eLetters Log in to view full text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Science Translational Medicine Vol 8 Issue 321 13 January 2016 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Cancer care looks ROSEy Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools Cancer care looks ROSEy By Marshaleen Henriques Forsythe Science Translational Medicine 13 Jan 2016 321ec5 Rapid on site evaluation ROSE potentially enhances bronchoscopic methods for lung cancer genotyping Citation Manager Formats BibTeX Bookends EasyBib EndNote tagged EndNote 8 xml Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS

    Original URL path: http://stm.sciencemag.org/content/8/321/321ec5 (2016-02-10)
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  • Cancer care looks ROSEy | Science Translational Medicine
    this author on PubMed Search for this author on this site Article Info Metrics eLetters Log in to view full text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Science Translational Medicine Vol 8 Issue 321 13 January 2016 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Cancer care looks ROSEy Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools Cancer care looks ROSEy By Marshaleen Henriques Forsythe Science Translational Medicine 13 Jan 2016 321ec5 Rapid on site evaluation ROSE potentially enhances bronchoscopic methods for lung cancer genotyping Citation Manager Formats BibTeX Bookends EasyBib EndNote tagged EndNote 8 xml Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Share Cancer care

    Original URL path: http://stm.sciencemag.org/content/8/321/321ec5.full (2016-02-10)
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  • Clocking in to the brain’s activity | Science Translational Medicine
    on Google Scholar Find this author on PubMed Search for this author on this site Article Info Metrics eLetters Log in to view full text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Science Translational Medicine Vol 8 Issue 321 13 January 2016 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Clocking in to the brain s activity Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools Clocking in to the brain s activity By Yo El Ju Science Translational Medicine 13 Jan 2016 321ec6 Aging alters the circadian rhythmicity of gene expression in the human brain Citation Manager Formats BibTeX Bookends EasyBib EndNote tagged EndNote 8 xml Medlars Mendeley Papers

    Original URL path: http://stm.sciencemag.org/content/8/321/321ec6 (2016-02-10)
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  • Clocking in to the brain’s activity | Science Translational Medicine
    Find this author on PubMed Search for this author on this site Article Info Metrics eLetters Log in to view full text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Science Translational Medicine Vol 8 Issue 321 13 January 2016 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Clocking in to the brain s activity Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools Clocking in to the brain s activity By Yo El Ju Science Translational Medicine 13 Jan 2016 321ec6 Aging alters the circadian rhythmicity of gene expression in the human brain Citation Manager Formats BibTeX Bookends EasyBib EndNote tagged EndNote 8 xml Medlars Mendeley Papers RefWorks Tagged Ref

    Original URL path: http://stm.sciencemag.org/content/8/321/321ec6.full (2016-02-10)
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