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  • Noncoding RNA plugs into a proinflammatory circuit | Science Translational Medicine
    Family Comprehensive Cancer Center UCSF CA 94158 USA E mail Alexander marson ucsf edu Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Info Metrics eLetters Log in to view full text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Science Translational Medicine Vol 8 Issue 321 13 January 2016 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Noncoding RNA plugs into a proinflammatory circuit Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools Noncoding RNA plugs into a proinflammatory circuit By Alexander Marson Science Translational Medicine 13 Jan 2016 321ec7 Rmrp a long noncoding RNA and DDX5 an RNA helicase

    Original URL path: http://stm.sciencemag.org/content/8/321/321ec7 (2016-02-10)
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  • Noncoding RNA plugs into a proinflammatory circuit | Science Translational Medicine
    Center UCSF CA 94158 USA E mail Alexander marson ucsf edu Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Info Metrics eLetters Log in to view full text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Science Translational Medicine Vol 8 Issue 321 13 January 2016 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Noncoding RNA plugs into a proinflammatory circuit Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools Noncoding RNA plugs into a proinflammatory circuit By Alexander Marson Science Translational Medicine 13 Jan 2016 321ec7 Rmrp a long noncoding RNA and DDX5 an RNA helicase are potential therapeutic

    Original URL path: http://stm.sciencemag.org/content/8/321/321ec7.full (2016-02-10)
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  • An integrative analysis sheds light on methylation profiles | Science Translational Medicine
    on Google Scholar Find this author on PubMed Search for this author on this site Article Info Metrics eLetters Log in to view full text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Science Translational Medicine Vol 8 Issue 321 13 January 2016 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following An integrative analysis sheds light on methylation profiles Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools An integrative analysis sheds light on methylation profiles By Masako Suzuki Science Translational Medicine 13 Jan 2016 321ec8 Genetic influence is not negligible for testing DNA methylation profiles in human studies Citation Manager Formats BibTeX Bookends EasyBib EndNote tagged EndNote 8 xml Medlars

    Original URL path: http://stm.sciencemag.org/content/8/321/321ec8 (2016-02-10)
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  • An integrative analysis sheds light on methylation profiles | Science Translational Medicine
    Find this author on PubMed Search for this author on this site Article Info Metrics eLetters Log in to view full text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Science Translational Medicine Vol 8 Issue 321 13 January 2016 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following An integrative analysis sheds light on methylation profiles Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools An integrative analysis sheds light on methylation profiles By Masako Suzuki Science Translational Medicine 13 Jan 2016 321ec8 Genetic influence is not negligible for testing DNA methylation profiles in human studies Citation Manager Formats BibTeX Bookends EasyBib EndNote tagged EndNote 8 xml Medlars Mendeley Papers RefWorks

    Original URL path: http://stm.sciencemag.org/content/8/321/321ec8.full (2016-02-10)
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  • Erratum for the Research Article: “CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo” by P. J. Hanley, J. J. Melenhorst, S. Nikiforow, P. Scheinberg, J. W. Blaney, G. Demmler-Harrison, C. R. Cruz,… | Science Translational Medicine
    originally stated actually refers to a calculation of the diversity of TCRs in table S2 and was not meant to be included in the discussion None of these changes affect the overall conclusions of the study The errors have been corrected in the PDF and HTML full text versions of the paper Copyright 2016 American Association for the Advancement of Science Science Translational Medicine Vol 8 Issue 321 13 January 2016 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Erratum for the Research Article CMV specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo by P J Hanley J J Melenhorst S Nikiforow P Scheinberg J W Blaney G Demmler Harrison C R Cruz Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools Erratum for the Research Article CMV specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in

    Original URL path: http://stm.sciencemag.org/content/8/321/321er1 (2016-02-10)
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  • Quantifying prion disease penetrance using large population control cohorts | Science Translational Medicine
    Richard Knight National Creutzfeldt Jakob Disease Research Surveillance Unit Western General Hospital Edinburgh EH4 2XU UK Find this author on Google Scholar Find this author on PubMed Search for this author on this site Claudia Ponto National Reference Center for the Surveillance of Human Transmissible Spongiform Encephalopathies Georg August University Goettingen 37073 Germany Find this author on Google Scholar Find this author on PubMed Search for this author on this site Inga Zerr National Reference Center for the Surveillance of Human Transmissible Spongiform Encephalopathies Georg August University Goettingen 37073 Germany Find this author on Google Scholar Find this author on PubMed Search for this author on this site Theo F J Kraus Center for Neuropathology and Prion Research ZNP Ludwig Maximilians University Munich 81377 Germany Find this author on Google Scholar Find this author on PubMed Search for this author on this site Sabina Eigenbrod Center for Neuropathology and Prion Research ZNP Ludwig Maximilians University Munich 81377 Germany Find this author on Google Scholar Find this author on PubMed Search for this author on this site Armin Giese Center for Neuropathology and Prion Research ZNP Ludwig Maximilians University Munich 81377 Germany Find this author on Google Scholar Find this author on PubMed Search for this author on this site Miguel Calero Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas Instituto de Salud Carlos III Madrid 28031 Spain Find this author on Google Scholar Find this author on PubMed Search for this author on this site Jesús de Pedro Cuesta Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas Instituto de Salud Carlos III Madrid 28031 Spain Find this author on Google Scholar Find this author on PubMed Search for this author on this site Stéphane Haïk INSERM U 1127 CNRS UMR 7225 Sorbonne Universités Pierre and Marie Curie University Paris 06 UMR S 1127 Institut du Cerveau et de la Moelle Epinière 75013 Paris France Assistance Publique Hôpitaux de Paris AP HP Cellule Nationale de Référence des Maladies de Creutzfeldt Jakob Groupe Hospitalier Pitié Salpêtrière F 75013 Paris France Find this author on Google Scholar Find this author on PubMed Search for this author on this site Jean Louis Laplanche AP HP Service de Biochimie et Biologie Moléculaire Hôpital Lariboisière 75010 Paris France Find this author on Google Scholar Find this author on PubMed Search for this author on this site Elodie Bouaziz Amar AP HP Service de Biochimie et Biologie Moléculaire Hôpital Lariboisière 75010 Paris France Find this author on Google Scholar Find this author on PubMed Search for this author on this site Jean Philippe Brandel INSERM U 1127 CNRS UMR 7225 Sorbonne Universités Pierre and Marie Curie University Paris 06 UMR S 1127 Institut du Cerveau et de la Moelle Epinière 75013 Paris France Assistance Publique Hôpitaux de Paris AP HP Cellule Nationale de Référence des Maladies de Creutzfeldt Jakob Groupe Hospitalier Pitié Salpêtrière F 75013 Paris France Find this author on Google Scholar Find this author on PubMed Search for this author on this site Sabina Capellari Istituto di Ricovero e Cura a Carattere Scientifico Institute of Neurological Sciences Bologna 40123 Italy Department of Biomedical and Neuromotor Sciences University of Bologna Bologna 40126 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Piero Parchi Istituto di Ricovero e Cura a Carattere Scientifico Institute of Neurological Sciences Bologna 40123 Italy Department of Biomedical and Neuromotor Sciences University of Bologna Bologna 40126 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Anna Poleggi Department of Cell Biology and Neurosciences Istituto Superiore di Sanità Rome 00161 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Anna Ladogana Department of Cell Biology and Neurosciences Istituto Superiore di Sanità Rome 00161 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Anne H O Donnell Luria Program in Medical and Population Genetics Broad Institute of Massachusetts Institute of Technology MIT and Harvard Cambridge MA 02142 USA Analytical and Translational Genetics Unit Massachusetts General Hospital Boston MA 02114 USA Division of Genetics and Genomics Boston Children s Hospital Boston MA 02115 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Konrad J Karczewski Program in Medical and Population Genetics Broad Institute of Massachusetts Institute of Technology MIT and Harvard Cambridge MA 02142 USA Analytical and Translational Genetics Unit Massachusetts General Hospital Boston MA 02114 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Jamie L Marshall Program in Medical and Population Genetics Broad Institute of Massachusetts Institute of Technology MIT and Harvard Cambridge MA 02142 USA Analytical and Translational Genetics Unit Massachusetts General Hospital Boston MA 02114 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Michael Boehnke Department of Biostatistics and Center for Statistical Genetics University of Michigan School of Public Health Ann Arbor MI 48109 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Markku Laakso Department of Medicine University of Eastern Finland and Kuopio University Hospital Kuopio 70210 Finland Find this author on Google Scholar Find this author on PubMed Search for this author on this site Karen L Mohlke Department of Genetics University of North Carolina School of Medicine Chapel Hill NC 27599 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Anna Kähler Karolinska Institutet Stockholm SE 171 77 Sweden Find this author on Google Scholar Find this author on PubMed Search for this author on this site Kimberly Chambert Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge MA 02142 USA Find this author on Google Scholar Find this author on PubMed Search

    Original URL path: http://stm.sciencemag.org/content/8/322/322ra9 (2016-02-10)
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  • Host gene expression classifiers diagnose acute respiratory illness etiology | Science Translational Medicine
    Find this author on Google Scholar Find this author on PubMed Search for this author on this site Charles B Cairns Department of Emergency Medicine University of North Carolina School of Medicine Chapel Hill NC 27599 USA Department of Emergency Medicine University of Arizona Health Sciences Center Tucson AZ 85724 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Anja K Jaehne Department of Emergency Medicine Henry Ford Hospital Wayne State University Detroit MI 48202 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Emanuel P Rivers Department of Emergency Medicine Henry Ford Hospital Wayne State University Detroit MI 48202 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Ronny M Otero Department of Emergency Medicine Henry Ford Hospital Wayne State University Detroit MI 48202 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Aimee K Zaas Center for Applied Genomics and Precision Medicine Department of Medicine Duke University Durham NC 27708 USA Division of Infectious Diseases and International Health Department of Medicine Duke University Durham NC 27710 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Stephen F Kingsmore Rady Pediatric Genomic and Systems Medicine Institute Rady Children s Hospital San Diego CA 92123 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Joseph Lucas Center for Applied Genomics and Precision Medicine Department of Medicine Duke University Durham NC 27708 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Vance G Fowler Jr Division of Infectious Diseases and International Health Department of Medicine Duke University Durham NC 27710 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Lawrence Carin Center for Applied Genomics and Precision Medicine Department of Medicine Duke University Durham NC 27708 USA Department of Electrical and Computer Engineering Duke University Durham NC 27708 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Geoffrey S Ginsburg Center for Applied Genomics and Precision Medicine Department of Medicine Duke University Durham NC 27708 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Christopher W Woods Center for Applied Genomics and Precision Medicine Department of Medicine Duke University Durham NC 27708 USA Division of Infectious Diseases and International Health Department of Medicine Duke University Durham NC 27710 USA Section for Infectious Diseases Medicine Service Durham Veteran s Affairs Medical Center Durham NC 27705 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You

    Original URL path: http://stm.sciencemag.org/content/8/322/322ra11 (2016-02-10)
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  • CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival | Science Translational Medicine
    Scholar Find this author on PubMed Search for this author on this site Chyi Chia Richard Lee Laboratory of Pathology Center for Cancer Research National Cancer Institute NIH Bethesda MD 20892 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site John R Perfect Duke University School of Medicine Durham NC 27708 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Barbara D Alexander Duke University School of Medicine Durham NC 27708 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Bart Jan Kullberg Department of Internal Medicine and Radboud Center for Infectious Diseases Radboud University Medical Center Nijmegen 6500HB Netherlands Find this author on Google Scholar Find this author on PubMed Search for this author on this site Mihai G Netea Department of Internal Medicine and Radboud Center for Infectious Diseases Radboud University Medical Center Nijmegen 6500HB Netherlands Find this author on Google Scholar Find this author on PubMed Search for this author on this site Philip M Murphy Molecular Signaling Section Laboratory of Molecular Immunology National Institute of Allergy and Infectious Diseases NIH Bethesda MD 20892 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Michail S Lionakis Fungal Pathogenesis Unit Laboratory of Clinical Infectious Diseases National Institute of Allergy and Infectious Diseases National Institutes of Health NIH Bethesda MD 20892 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the abstract View Full Text Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Join Subscribe Purchase Article Activate Member Account Renew Subscription Recommend a subscription to your library Help for librarians Candida camera The yeast Candida albicans can live symbiotically in human gut and skin but when it penetrates the mucosal barrier and enters the bloodstream it can cause life threatening systemic infection Now Swamydas et al provide a look at how neutrophils control Candida They show that the neutrophil selective chemokine receptor Cxcr1 plays a critical role in antifungal host defense Mice lacking Cxcr1 were more susceptible to systemic candidiasis because of defective neutrophil mediated fungal killing Neutrophils from humans with a mutant CXCR1 allele also had defective fungal response These data suggest that Cxcr1 is critical for innate host defense against fungal infection Abstract Systemic Candida albicans infection causes high morbidity and mortality and is now the leading cause of nosocomial bloodstream infection in the United States Neutropenia is a major risk factor for poor outcome in infected patients however the molecular factors that mediate neutrophil trafficking and effector function during infection are poorly defined Using a mouse model of systemic candidiasis we found that the neutrophil selective CXC chemokine receptor Cxcr1 and

    Original URL path: http://stm.sciencemag.org/content/8/322/322ra10 (2016-02-10)
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