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  • Vaccine Against Campylobacter jejuni | TechLink
    range and the second demonstrated 100 efficacy in 14 animals p 003 compared to PBS immunized animals The vaccine composition is such that it will not induce Guillain Barré Syndrome Capsular polysaccharides have only recently been recognized in C jejuni and have been shown to contribute to serospecificity of the Penner or heat stable HS serotyping scheme Conjugate capsular vaccines have shown success against other invasive mucosal pathogens such as Streptococcus pneumonia Haemophilus influenza Group B Streptococci Salmonella typhi and Neisseria meningitis In addition to the vaccine a safe human challenge model for Phase II testing of C jejuni vaccines has been developed The strain used in this model lacks ganglioside mimicry and cannot cause Guillain Barré Syndrome Benefits Primate testing data available under a confidentiality agreement Vaccine does not elicit autoimmune responses such as Guillain Barré Syndrome Based on a proven vaccine platform for mucosal pathogens Human challenge model that does not elicit autoimmune responses such as Guillain Barré Syndrome is currently in development the capsule of this challenge strain is the same as the capsule conjugate vaccine that has shown efficacy in primates Ongoing research program The Opportunity Intellectual Property US Patent Application 11 524 057 filed September

    Original URL path: http://techlinkcenter.org/summaries/vaccine-against-campylobacter-jejuni (2016-02-09)
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  • Whole Blood Cholinesterase Assay | TechLink
    and can be semi automated through the use of currently available laboratory equipment The assay uses unprocessed whole blood only 100 uL obtained by minimally invasive blood sampling techniques Results are accurate because the assay uses a proprietary formula to determine AChE and BChE levels based on measurements of three different substrates for each The assay has been used to support two FDA studies Additional FDA testing is underway to further validate this technology Other tests to determine cholinesterase in blood suffer from several significant drawbacks including lack of standardization long turn around times inhibitors or centrifugation to measure both AChE and BChE and difficulty in comparing results between different laboratories The new whole blood system does not suffer from those shortcomings Benefits Simple Easy blood sample collection and no processing required Rapid and semi automated analysis Accurate and reproducible results The Opportunity Applications Chemical warfare and bioterror agent detection Pesticide exposure measurement in humans and animals Screening for drug nerve agent or anesthetic sensitivity Detection and or monitoring of disease states Monitoring of patients treated with cholinesterase inhibitors This technology is available through patent license of US Patent 6 746 850 Further research and development of the technology can

    Original URL path: http://techlinkcenter.org/summaries/whole-blood-cholinesterase-assay (2016-02-09)
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  • Multifunctional Blood Substitute | TechLink
    a polymerized hemoglobin based oxygen carrier HBOC and can also comprise pharmacological interventions Factor VIIa has been approved by the FDA for hemostatic indications and HBOCS address hypotensive or low volume resuscitation and may maximize the benefits of fluid replacement Additional pharmacological interventions may include platelet membranes antiinflammatory agents and nitric oxide donors Benefits More Effective Combination of HBOC and procoagulation factor more closely mimics the life saving characteristics of real whole blood Shelf Stable Product has fewer storage restrictions than traditional blood products Portable Fewer storage restrictions means the product can be utilized in the field and in transit The Opportunity Trauma is the leading cause of mortality among young adults and causes significant disability among survivors Hemorrhage accounts for most civilian deaths and about one third of combat deaths Current pre hospital interventions such as crystalloids and colloids have a significant but inadequate effect on survivability This US Navy intervention aims at higher survivability and does not require refrigeration like whole blood The US Navy has done animal studies and is seeking a partner to help develop lead clinical trials and commercialize the technology US patent application 2007 0265195 has published and a PCT has been filed for

    Original URL path: http://techlinkcenter.org/summaries/multifunctional-blood-substitute (2016-02-09)
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  • Safety Adaptor for Foley Catheter | TechLink
    in the bladder to hold the catheter in place Unfortunately not all catheters are removed by deflating the anchoring balloon Sometimes catheters are pulled from the bladder with the anchoring balloon inflated by accident or by a patient in a fit of anger delusion or owing to the affects of sedatives This can cause serious injury to the patient To protect patients from this type of injury Army medical personnel have designed and prototyped a safety adaptor which can be attached to any Foley catheter The adaptor can absorb the fluid of the anchoring balloon in case of accidental or sudden removal of the catheter from the bladder thereby reducing serious injury Benefits The adaptor attaches to existing catheters no need to re engineer the catheter This easy to connect safety device can be added at any time to the catheter of a patient It is easily removable for normal deflation of anchor balloon External to sterile field Prototype available The Opportunity The US Army is seeking a licensee for this patent pending technology Publication Number US 2008 0009793 Improving the method for fastening the elastic membrane may be required Collaborative research and development CRADA opportunities may be possible Contacts

    Original URL path: http://techlinkcenter.org/summaries/safety-adaptor-foley-catheter (2016-02-09)
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  • Hantavirus Technology Suite: Vaccines, Prophylactics, Therapeutics, and Antibodies & Pseudovirions for Diagnostics and Other Applications | TechLink
    treatment options and the technologies hold promising therapeutic potential The HFRS work has led to highly immunogenic neutralizing antibodies Puumala and Hantaan virus vaccine candidates A Seoul virus DNA vaccine also has been developed The Hantaan and Seoul vaccines have both been shown to create cross neutralization activity against Dobrava virus The HPS work has focused on Andes virus and Sin Nombre virus The Puumala vaccine has been demonstrated to provide cross protection against Andes virus in an animal model The HFRS vaccine based on Puumala Hantaan DNA plasmids has undergone two FDA Phase I studies and is entering Phase II Preclinical efficacy and GMP production work for an HPS vaccine based on Andes Sin Nombre DNA plasmids is underway Various delivery techniques have been explored including muscle and skin electroporation gene guns and the PharmaJet needle free injectors In addition to the vaccine work the underlying DNA plasmids have applications for various prophylactics and therapeutics In vivo work has demonstrated the efficacy of post exposure prophylaxis using antibodies produced with the DNA vaccines The first ever demonstration of in vivo efficacy of any antiviral product using DNA vaccine duck egg system provided protection against Andes virus in hamsters treated 5 and 8 days after Andes virus exposure Antibodies and Pseudovirions for Diagnostic and Other Applications The US Army Medical Research Institute of Infectious Diseases USAMRIID has developed and patented an array of M segment DNA vaccine plasmids The plasmids have been used to make neutralizing binding antibodies suitable for diagnostic applications Additionally the Army has developed standardized procedures for using the same DNA vaccine plasmids to produce pseudovirions These virus like particles can be used to measure neutralizing and non neutralizing antibody responses to hantaviruses and other viruses Benefits Extensive DNA Suite M segment DNA isolated and optimized for

    Original URL path: http://techlinkcenter.org/summaries/hantavirus-technology-suite-vaccines-prophylactics-therapeutics-and-antibodies (2016-02-09)
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  • Antimicrobial Peptide in Antiplaque Chewing Gum | TechLink
    selective toxicity for prokaryotes The result is efficacy against supragingival plaque bacteria but little effect on normal oral flora and low potential for drug resistance KSL W is readily adsorbed to toothlike materials and effectively desorbed over time this peptide also has good stability in saliva The U S Army Dental and Trauma Research Detachment has formulated this peptide into an antiplaque chewing gum APCG for sustained and improved delivery in the mouth In addition to KSL W APCG contains a xylitol base calcium phosphate as a mild abrasive and cetylpyridinium chloride which causes a large increase in the rate and extent of KSL W release This peptide readily degrades in gastric environments APCG has extensive pre clinical testing data and is funded to enter FDA Phase I trials shortly Benefits Augments natural defense KSL W acts in a manner similar to the body s defenses and augments those systems in a manner that targets threats while maintaining beneficial oral flora Effective Efficacious against plaque causing bacteria including methicillin resistant Staphylococcus aureus Pseudomonas aeruginosa and cariogenic bacteria Streptococcus mutans S sobrinus and Lactobacillus acidophilus Broad spectrum capabilities KSL W has also been shown to kill fungi including Candida albicans and

    Original URL path: http://techlinkcenter.org/summaries/antimicrobial-peptide-antiplaque-chewing-gum (2016-02-09)
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  • Temporary Prosthesis | TechLink
    months delaying the physical therapy and training needed for a patient to regain function Use of this device can be initiated the day following surgery to allow the patient to begin prosthetic training The pre prosthetic device is operated by the patient raising his arm with the shoulder muscles while the device is gently attached to the arm The device will flex allowing for hand to mouth tasks as well as straight arm reaching tasks Various tools can be attached to the arm for use by the patient The device can be fabricated by any therapist familiar with custom splints in 1 to 1 5 hours Use of this device allows patients to regain some independence in daily activities with less reliance on family or nursing staff an important aspect of recovery Excellent application for burn victims where prosthetic fitting is often delayed by slow healing wounds or in developing countries where cost of medical care prevents amputees from receiving prosthetics Benefits Requires minimal gross body movement to function Can be used the day following surgery Flexible cuff adjustment for arm size changes Performs hand to mouth and reaching tasks Can be fabricated in any rehabilitation clinic No other temporary

    Original URL path: http://techlinkcenter.org/summaries/temporary-prosthesis (2016-02-09)
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  • Warfighter Sleep Kit | TechLink
    order to increase their alertness and job effectiveness Image Right The Technology The sleep kit was developed by the Air Mobility Command as a part of the comprehensive Alertness Management in Military Operations initiative from the Defense Safety Oversight Council The sleep kit contains the following A pocket sized guide containing essential facts on sleep A form fitting sleep mask to help block environmental light and ear plugs to help block ambient noise A DVD that includes AMMO Lite a personal sleep diary that allows the user to estimate his her operational readiness based on sleep schedule A Sleep Assessment Program that helps identify common sleep issues with tools to deal with these issues Warrior Mind Training videos progressive relaxation and behavioral techniques to assist in falling asleep Information on shift work the physiology of sleep and more Benefits Affects alertness and performance of users including better response time and better decision making Helps alleviate long term sleep deprivation effects of weight gain and other physical problems Cost effective and easy to use The Opportunity The Sleep Kit has been prototyped and is in preliminary testing This technology is available for licensing from the US Transportation Command Contacts Sean Patten

    Original URL path: http://techlinkcenter.org/summaries/warfighter-sleep-kit (2016-02-09)
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