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  • Vincent Caprio's Blog Evolving Innovations » Blog Archive » NanoBusiness Interview – Anil R. Diwan, President & Chairman, NanoViricides
    are successful we believe we will be able to create nanoviricides which do not lose much effectiveness when the virus mutates That is the holy grail of HIV therapy We already have significant initial success in animal studies We found that some of the nanoviricide drug candidates gave equal effectiveness against HIV 1 infection as the three drug standard therapy called HAART highly active antiretroviral therapy HAART is highly effective but quite noxious It causes vomiting lack of appetite cachexia weight loss and lipid redistribution hunchback effect We did not see any signs of potential adverse effects in animals treated with HIVCide candidates unlike in the HAART treated mice HIV animal studies are extremely expensive This program has been moving very slowly But we believe we will continue to build on our success as we have done with Influenza Now about the role of nanotechnology in HIV AIDS Nanotechnology can provide research tools like more sensitive tests and parallel testing which can speed up progress We believe that the nanoviricides technology may already have enabled Functional Cure of HIV AIDS if our animal study results hold in humans The next challenge is a true or complete cure This would require eliminating the reservoirs of HIV in addition to the functional cure I think nanotechnology holds a great promise here Personally I don t believe there is a solution to this problem without using nanotechnology SW NanoViricides is working on treatment for Rabies What is novel about your approach to treating Rabies AD Rabies is a uniformly fatal infection There are very few patients who have survived and they are all severely disabled A single rabies virus particle is sufficient to cause death in humans The available antibody based treatments have shown protection in animal studies It is not known if these treatments are therapeutic in humans As I said earlier nanoviricides are far beyond antibody therapies in terms of their design If an antibody therapy exists then we can develop a nanoviricide therapy Animal studies for rabies are a contrived model at best However the very first anti rabies nanoviricides we developed demonstrated a therapeutic effect i e treatment after infection in mice In one experiment 30 of the animals infected with lethal dose of rabies virus survived due to nanoviricide treatment Rabies therapy development has many challenges It is not an important disease in the developed world so there is very limited funding if any There are also many scientific challenges Rabies virus which is usually introduced by an animal bite such as an infected bat dog raccoon etc quickly travels to the brain through nerves There it colonizes inside the brain cells The time from a bite to rabies disease symptoms in humans can vary from a few days to decades When the patient presents with symptoms it may already be too late There is a limited commercial market for this treatment That combined with the scientific challenges has made us put it on the back burner Nevertheless we keep working on it in the background SW You are also developing treatments for Dengue Tell us about those and what makes them unique AD Dengue virus challenges are very unique It has developed a unique mechanism to defeat the human immune system The most severe manifestation of it is called ADE for Antibody Dependent Enhancement There are four types of dengue viruses I to IV with many subtypes and strains When a person gets infected with any one of these four types say type X the person will usually recover It feels like a flu that lasts as much as three weeks and causes such pain it is called breakbone fever When the same person gets infected a few years later with a different dengue virus type say Y this is called a secondary infection The immune system produces antibodies against type X However these antibodies are not good at stopping Y The type Y virus binds to the antibodies the virus bearing antibodies then bind to the Fc receptor positive cells of the immune system and the virus thus hitches a ride into these cells and causes an even more dramatic infection than if there were no antibodies This leads to severe dengue disease hemorrhagic fever and eventually death WHO estimates that the fatality rates from the severe dengue cases may be as high as 20 People in most of the tropical world have already been exposed to primary dengue WHO estimates that several billion humans or almost 40 of the world s population are at risk of secondary dengue There can be a high fatality rate epidemic if a dengue virus mutates to become more vicious Thus it is necessary to develop a drug against dengue that attacks all four major types and all the subtypes and strains and possible mutants Vaccines have been developed but did not show promising results in their earlier incarnations This may be because of the ADE effect Currently a tetravalent vaccine is in clinical trials and appears to show protection Nevertheless such vaccines are not expected to protect 100 of the people that take them but possibly only about 30 50 Besides vaccines usually fail with the emergence of mutated viruses And when a person develops a disease we still need to have a treatment We started working on Dengue ca 2007 2008 The first cell culture and animal studies were conducted in Professor Eva Harris lab at UC Berkeley just about a year ago We found that one of the anti dengue nanoviricide candidates demonstrated as much as 50 survival in mice This model was an ADE emulating model To date we are not aware of any other therapeutics developments that are so successful in the ADE mouse model of dengue We presented these results at the International Dengue conference in Puerto Rico that was organized by the CDC and NIH among others in February 2011 It appears that at present we may be the only company with a

    Original URL path: http://www.vincentcaprio.org/nanobusiness-interview-anil-r-diwan-president-chairman-nanoviricides (2016-05-02)
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  • Vincent Caprio's Blog Evolving Innovations » Blog Archive » Senate Convenes Nano Caucus Briefing, Weds, June 22nd, Washington, DC
    of the National Nanotechnology Initiative and focused on some of the many commercial successes of nanotechnology commercialization and the many ways these products are improving energy consumption medical care and treatment greener chemistry and providing other benefits Jim Hussey Chief Executive Officer Nanoink Inc gave a spirited presentation on some of the commercial challenges facing the nano community and the need for universities investors and other nano stakeholders to stimulate investment in nanotechnology Travis Earles Ph D Advanced Materials and Nanotechnology Initiatives Lockheed Martin Corporation and former Assistant Director of Nanotechnology White House Office of Science and Technology Policy shared his insights as a former policymaker and his transition to the private sector Finally Frank A Ignazzitto Vice President Government Business QD Vision Inc explained how QD Vision s commercialization of quantum dot technology will greatly conserve energy and enhance significantly the resolution of screens in consumer and related electronics among other benefits Leave a Reply Name required Mail will not be published required Website Pages Vincent s Bio Vincent s Friends Become a WIAF Individual Member Become a NanoBCA Individual Member Contact Me Vincent Caprio on You Tube Discussing Water Infrastructure Water 2 0 Conference February 26 2013 30 Rockefeller Center New York NYC 5th Annual Nanotech Commercialization Conference April 9 10 2013 Wake Forest Biotech Place Winston Salem NC NanoBusiness Commercialization Association 11th Annual NanoBusiness Conference September 5 7 2012 Boston MA Water Innovations Alliance Home Key Posts Nanotech Commercialization Conference April 9 10 2013 Wake Forest Biotech Place Winston Salem NC Useful Links National Nanotechnology Initiative InterNano Resources for Nanomanufacturing Center of Innovation for Nanobiotechnology Nano and Other Emerging Chemical Technologies Blog CalNIN California Nano Industry Network Bergeson Campbell PC National Nanotechnology Coordination Office Archives April 2016 March 2016 February 2016 December 2015 November 2015 October 2015

    Original URL path: http://www.vincentcaprio.org/senate-convenes-nano-caucus-briefing-wednesday-june-22nd. (2016-05-02)
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  • Vincent Caprio's Blog Evolving Innovations » Blog Archive » Nanotechnology Caucus Lecture: Nanotechnology 101 – June 22, 2011, Washington, DC
    nano gov 11 40 12 00 Travis Earles Ph D Invited Advanced Materials and Nanotechnology Initiatives Lockheed Martin Corporation Bethesda MD formerly Assistant Director of Nanotechnology White House Office of Science and Technology Policy 12 00 12 20 Jim Hussey Chief Executive Officer NanoInk Moving from lab to marketplace what nanotechnology needs http www nanoink net 12 20 12 40 Frank Ignazzitto Vice President Government Business QD Vision Inc Watertown MA http www qdvision com 12 40 12 55 Scott Livingston Chairman and Chief Executive Officer Livingston Securities http www livingstonsecurities com 12 55 1 00 Closing Remarks Vincent Caprio Executive Director NanoBusiness Commercialization Association Lynn Bergeson Partner Bergeson Campbell http www lawbc com Phil Lippel Nanotechnology Consultant Regards Vincent Caprio Serving the Nanotechnology Community for Over a Decade Executive Director NanoBusiness Commercialization Association 203 733 1949 vincent nanobca org www nanobca org Leave a Reply Name required Mail will not be published required Website Pages Vincent s Bio Vincent s Friends Become a WIAF Individual Member Become a NanoBCA Individual Member Contact Me Vincent Caprio on You Tube Discussing Water Infrastructure Water 2 0 Conference February 26 2013 30 Rockefeller Center New York NYC 5th Annual Nanotech Commercialization Conference April 9 10 2013 Wake Forest Biotech Place Winston Salem NC NanoBusiness Commercialization Association 11th Annual NanoBusiness Conference September 5 7 2012 Boston MA Water Innovations Alliance Home Key Posts Nanotech Commercialization Conference April 9 10 2013 Wake Forest Biotech Place Winston Salem NC Useful Links National Nanotechnology Initiative InterNano Resources for Nanomanufacturing Center of Innovation for Nanobiotechnology Nano and Other Emerging Chemical Technologies Blog CalNIN California Nano Industry Network Bergeson Campbell PC National Nanotechnology Coordination Office Archives April 2016 March 2016 February 2016 December 2015 November 2015 October 2015 September 2015 August 2015 July 2015 June 2015 May 2015

    Original URL path: http://www.vincentcaprio.org/nanotechnology-caucus-lecture-nanotechnology-101-june-22-2011-washington-dc (2016-05-02)
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  • Vincent Caprio's Blog Evolving Innovations » Blog Archive » NanoBusiness Public Policy Counsel Regulatory Update – June 2011
    material or end product has at least one dimension in the nanoscale range approximately 1 nm to 100 nm or 2 Whether an engineered material or end product exhibits properties or phenomena including physical or chemical properties or biological effects that are attributable to its dimension s even if these dimensions fall outside the nanoscale range up to one micrometer Importantly FDA noted that these considerations apply not only to new products but also may apply when manufacturing changes alter the dimensions properties or effects of an FDA regulated product or any of its components FDA also indicated that the criteria are subject to change in the future as more data becomes available The full document including instructions for submitting comments within 60 days is available at http www fda gov RegulatoryInformation Guidances ucm257698 htm The White House also issued a joint memorandum on the regulation of nanotechnology from the Office of Science and Technology Policy the Office of Management and Budget s Office of Information and Regulatory Affairs and the office of the U S Trade Representative The memo provides guidance to agency heads stating that regulators should use flexible adaptive and evidence based approaches that avoid wherever possible hindering innovation and trade while fulfilling the federal government s responsibility to protect public health and the environment The memo lists principles that agencies should follow It is available at http www whitehouse gov sites default files omb inforeg for agencies nanotechnology regulation and oversight principles pdf This message is for informational purposes and does not contain or convey legal advice The information herein should not be used or relied upon in regard to any particular facts or circumstances without first consulting a lawyer These recent regulatory developments discussed by Paul will have an impact on our Nanotechnology Community I

    Original URL path: http://www.vincentcaprio.org/nanobusiness-public-policy-counsel-regulatory-update-june-2011 (2016-05-02)
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  • Vincent Caprio's Blog Evolving Innovations » Blog Archive » NanoBusiness Commercialization Association – Nano News Spring Vol. 3
    3A Index 3 28Top Stories 2 29 29 Government agencies concerned about potential health and environmental risks are stepping up efforts to gather data on nanomaterials http www industryweek com articles information please 19236 aspx Publicly Traded Nanotechnology Companies Stock Results see attached spreadsheet ARPA E energy leader to meet with NanoMech NanoMech lubricants provide manufacturing competitiveness and decrease America s dependency on foreign oil http classic cnbc com id 43308105 PLEASE SAVE THE DATE for our 10th Annual NanoBusiness Conference Nanomanufacturing Summit 2011 September 25 27 2011 http www internano org nms2011 Seaport World Trade Center Boston MA http www seaportboston com meetings and events overview aspx Hotel Seaport Hotel connected to the World Trade Center http www seaportboston com Regards Vincent Caprio Serving the Nanotechnology Community for Over a Decade Executive Director NanoBusiness Commercialization Association 203 733 1949 vincent nanobca org www nanobca org NanoBCA Publicly Traded Nanotech Stocks May 2011 Update Leave a Reply Name required Mail will not be published required Website Pages Vincent s Bio Vincent s Friends Become a WIAF Individual Member Become a NanoBCA Individual Member Contact Me Vincent Caprio on You Tube Discussing Water Infrastructure Water 2 0 Conference February 26 2013 30 Rockefeller Center New York NYC 5th Annual Nanotech Commercialization Conference April 9 10 2013 Wake Forest Biotech Place Winston Salem NC NanoBusiness Commercialization Association 11th Annual NanoBusiness Conference September 5 7 2012 Boston MA Water Innovations Alliance Home Key Posts Nanotech Commercialization Conference April 9 10 2013 Wake Forest Biotech Place Winston Salem NC Useful Links National Nanotechnology Initiative InterNano Resources for Nanomanufacturing Center of Innovation for Nanobiotechnology Nano and Other Emerging Chemical Technologies Blog CalNIN California Nano Industry Network Bergeson Campbell PC National Nanotechnology Coordination Office Archives April 2016 March 2016 February 2016 December 2015 November 2015 October

    Original URL path: http://www.vincentcaprio.org/nanobusiness-commercialization-association-nano-news-spring-vol-3 (2016-05-02)
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  • Vincent Caprio's Blog Evolving Innovations » Blog Archive » NanoBusiness Interview – Jess Jankowski, President & CEO, Nanophase
    those colors but many would prefer the natural look of their wood and simply want it to last longer We have seen that our nanomaterials can improve the effectiveness of coatings significantly particularly in the transparent and lighter pigmented semi transparent applications We are working with customers to take the basic technology to market in both semi transparent and completely transparent wood coatings This is an area where we hold a significant advantage over the tradeoffs that historically had to be made protection vs transparency Our solutions offer the market both SW What are some of the futuristic nanomaterials applications Nanophase is working on that you can share with us JJ Working at a small scale with significant control over the particles has provided potentially huge energy applications that we are working on although it will take some time to determine viability Very thin transparent coatings also present strong potential advantages in plastics applications We have recently devised a method for adding our materials into several traditional plastics fabrication processes and are working with alpha customers on different applications Either of these concept areas could launch a company today but we are looking at them as additional areas for the strategic growth of our company which already has a good history and understanding in creating and then manufacturing these solutions SW Do you sense there is a misconception today among policymakers companies and the general public about nanomaterials JJ The unknown is inherently scary People who don t know what we do often assume that we are making little robots that will take over the world or unstoppable microbes What we are really doing is improving the forms or formats of materials that have been used for a very long time The data we see supports the safety of our products and we believe we meet every available standard of safety in our manufacturing processes I can only address our products many companies are creating products at a nano scale for all sorts of applications today that I m less familiar with and I m sure some will have issues and others won t just like any other business segment I believe we re seeing a softening of this paranoia in the marketplace and in legislative circles SW What kind of testing has Nanophase been involved with over the past decade either directly or indirectly with its nanomaterials and what are the results of those tests JJ This is a broad topic that I won t try to address completely I think the best way might be to discuss how we at Nanophase handle our Environmental Health and Safety EH S program Given that there aren t specific rules regarding the evaluation of nanomaterials in the workplace we have adopted and enhanced the existing safety regimes commonly and effectively used in the chemical industry We rely on NIOSH and OSHA standards as the starting point for our EH S program To their requirements compliance to chemical exposure rules and Permissible

    Original URL path: http://www.vincentcaprio.org/nanobusiness-interview-jess-jankowski-president-ceo-nanophase (2016-05-02)
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  • Vincent Caprio's Blog Evolving Innovations » Blog Archive » NanoBusiness Endorses Nanomaterials for Aerospace & Defense – Nano News Spring Vol. 2
    the 60s http history nasa gov moondec html Northwestern University Purchases NanoInk s NLP 2000 Desktop Nanofabrication System http www nanoink net press releases press release 3 29 2011 html U S Department of Energy to Invest in Innovalight http www tinytechvc com releasedetail cfm ReleaseID 580135 Nanosys Uses Cool Quantum Dot Technology to Make Displays More Colorful http www tinytechvc com releasedetail cfm ReleaseID 578893 Harris Harris Group Notes Sale of Quantum Computing System by D Wave Systems to Lockheed Martin Corporation http www tinytechvc com releasedetail cfm ReleaseID 580990 mPhase Technologies Granted Key U S Patent for Multi Chemistry Battery Architecture http campaign r20 constantcontact com render llr e8zakgdab v 001OOxHMyT1jj1SeQp1TUso ogiMZiKz1NGb7M8NuTBrZDdsIJlVzDl8VBqs3HnGWtaaqGHs xdWgjeosxRpdx QkO0uv7ONY0 iYf4 P4j bqsRlLWi0DDpg 3D 3D Testing Nano How Much Is Too Much http newhavenindependent org index php archives entry nano testing Nanomedicine the FDA Developing science on a case by case basis http www medcitynews com 2011 05 nanomedicine and the fda developing science on a case by case basis PLEASE SAVE THE DATE for our 10th Annual NanoBusiness Conference Nanomanufacturing Summit 2011 September 25 27 2011 http www internano org nms2011 Seaport World Trade Center Boston MA http www seaportboston com meetings and events overview aspx Hotel Seaport Hotel connected to the World Trade Center http www seaportboston com Regards Vincent Caprio Serving the Nanotechnology Community for Over a Decade Executive Director NanoBusiness Commercialization Association 203 733 1949 vincent nanobca org www nanobca org Leave a Reply Name required Mail will not be published required Website Pages Vincent s Bio Vincent s Friends Become a WIAF Individual Member Become a NanoBCA Individual Member Contact Me Vincent Caprio on You Tube Discussing Water Infrastructure Water 2 0 Conference February 26 2013 30 Rockefeller Center New York NYC 5th Annual Nanotech Commercialization Conference April 9

    Original URL path: http://www.vincentcaprio.org/nanobusiness-endorses-nanomaterials-for-aerospace-defense-nano-news-spring-vol-2 (2016-05-02)
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  • Vincent Caprio's Blog Evolving Innovations » Blog Archive » Vincent Caprio, Woodrow (Woody) Clark, PhD, 2007 Nobel Peace Prize Winner and Kirk Nagamine at the Blue Tech Valley Water Conference
    Individual Member Become a NanoBCA Individual Member Contact Me Vincent Caprio on You Tube Discussing Water Infrastructure Water 2 0 Conference February 26 2013 30 Rockefeller Center New York NYC 5th Annual Nanotech Commercialization Conference April 9 10 2013 Wake Forest Biotech Place Winston Salem NC NanoBusiness Commercialization Association 11th Annual NanoBusiness Conference September 5 7 2012 Boston MA Water Innovations Alliance Home Key Posts Nanotech Commercialization Conference April 9 10 2013 Wake Forest Biotech Place Winston Salem NC Useful Links National Nanotechnology Initiative InterNano Resources for Nanomanufacturing Center of Innovation for Nanobiotechnology Nano and Other Emerging Chemical Technologies Blog CalNIN California Nano Industry Network Bergeson Campbell PC National Nanotechnology Coordination Office Archives April 2016 March 2016 February 2016 December 2015 November 2015 October 2015 September 2015 August 2015 July 2015 June 2015 May 2015 April 2015 March 2015 February 2015 December 2014 November 2014 October 2014 September 2014 August 2014 July 2014 June 2014 May 2014 April 2014 March 2014 February 2014 January 2014 December 2013 November 2013 October 2013 September 2013 July 2013 May 2013 April 2013 March 2013 February 2013 January 2013 December 2012 November 2012 September 2012 August 2012 June 2012 May 2012 April 2012 March

    Original URL path: http://www.vincentcaprio.org/vincent-caprio-woodrow-woody-clark-phd-2007-nobel-peace-prize-winner-and-kirk-nagamine-at-the-blue-tech-valley-water-conference (2016-05-02)
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